{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:50:59Z","timestamp":1792083059707,"version":"4.4.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>\n            Brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are markers of heart failure. Although renal dysfunction may increase plasma concentrations, the magnitude of this effect has not been assessed in a head-to-head comparison between the clinically approved tests. We assessed the effect of compensated renal dysfunction on BNP (Triage BNP; Biosite) and NT-proBNP (elecsys proBNP; Roche) in 469 randomly selected stable outpatients after myocardial infarction (MI; Monitoring Trends and Determinants in Cardiovascular Diseases [MONICA] register Augsburg) who were characterized with respect to renal function (glomerular filtration rate [GFR]; Cockroft method) and left ventricular (LV) ejection fraction (EF) and mass (2D echocardiography). BNP and NT-proBNP were elevated in MI patients with LV dysfunction (LVD; EF &lt;35%) compared with MI patients with preserved EF (&gt;45%; BNP 139\u00b127 pg\/mL versus 75\u00b16; NT-proBNP 816\u00b1237 pg\/mL versus 243\u00b120; both\n            <jats:italic>P<\/jats:italic>\n            &lt;0.03). Among all MI patients, the prevalence of renal dysfunction (GFR &lt;85 mL\/min) was 24%. BNP and NT-proBNP were significantly elevated in MI patients with renal dysfunction (BNP 132\u00b117 pg\/mL versus 68\u00b14 without renal dysfunction; NT-proBNP 535\u00b180 pg\/mL versus 232\u00b119; both\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05), and both markers were correlated with GFR in univariate and multivariate analyses (all\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01). When binary cut-off values were stratified according to the absence or presence of renal dysfunction (BNP 75 pg\/mL and 125 pg\/mL, respectively; NT-proBNP 100 pg\/mL and 350pg\/mL, respectively), the predictive power of both markers for the detection of LVD increased substantially. BNP and NT-proBNP are almost similarly influenced by mild-to-moderate renal dysfunction. Renal dysfunction is a potential cause of elevated marker concentrations in the absence of LVD, and cut-off concentrations should be stratified according to renal function.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000170140.36633.8f","type":"journal-article","created":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:25:34Z","timestamp":1118103934000},"page":"118-123","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":155,"title":["Effect of Compensated Renal Dysfunction on Approved Heart Failure Markers"],"prefix":"10.1161","volume":"46","author":[{"given":"Andreas","family":"Luchner","sequence":"first","affiliation":[{"name":"From the Klinik und Poliklinik fu\u0308r Innere Medizin II (A.L., C.H., G.A.J.R., S.H.), University of Regensburg, Germany; GSF-Forschungszentrum (H.L.), Institut fu\u0308r Epidemiologie, Neuherberg, Germany; University of Schleswig-Holstein (H.S.), Campus Lu\u0308beck, Germany; and the KORA group (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[{"name":"From the Klinik und Poliklinik fu\u0308r Innere Medizin II (A.L., C.H., G.A.J.R., S.H.), University of Regensburg, Germany; GSF-Forschungszentrum (H.L.), Institut fu\u0308r Epidemiologie, Neuherberg, Germany; University of Schleswig-Holstein (H.S.), Campus Lu\u0308beck, Germany; and the KORA group (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Lo\u0308wel","sequence":"additional","affiliation":[{"name":"From the Klinik und Poliklinik fu\u0308r Innere Medizin II (A.L., C.H., G.A.J.R., S.H.), University of Regensburg, Germany; GSF-Forschungszentrum (H.L.), Institut fu\u0308r Epidemiologie, Neuherberg, Germany; University of Schleswig-Holstein (H.S.), Campus Lu\u0308beck, Germany; and the KORA group (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308nter A.J.","family":"Riegger","sequence":"additional","affiliation":[{"name":"From the Klinik und Poliklinik fu\u0308r Innere Medizin II (A.L., C.H., G.A.J.R., S.H.), University of Regensburg, Germany; GSF-Forschungszentrum (H.L.), Institut fu\u0308r Epidemiologie, Neuherberg, Germany; University of Schleswig-Holstein (H.S.), Campus Lu\u0308beck, Germany; and the KORA group (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[{"name":"From the Klinik und Poliklinik fu\u0308r Innere Medizin II (A.L., C.H., G.A.J.R., S.H.), University of Regensburg, Germany; GSF-Forschungszentrum (H.L.), Institut fu\u0308r Epidemiologie, Neuherberg, Germany; University of Schleswig-Holstein (H.S.), Campus Lu\u0308beck, Germany; and the KORA group (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Holmer","sequence":"additional","affiliation":[{"name":"From the Klinik und Poliklinik fu\u0308r Innere Medizin II (A.L., C.H., G.A.J.R., S.H.), University of Regensburg, Germany; GSF-Forschungszentrum (H.L.), Institut fu\u0308r Epidemiologie, Neuherberg, Germany; University of Schleswig-Holstein (H.S.), Campus Lu\u0308beck, Germany; and the KORA group (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.1.8319360"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118162"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.6.1558"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.5.H1684"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.3.8353861"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2001.24609"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50118"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.39.1.99"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4065\/76.11.1111"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343804"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.1.8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000141295.60857.30"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041365"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018080-00018"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02059-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.01.010"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.19.1921"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1746"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(98)00010-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000016642.15031.34"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.102.2.203"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000116764.53225.a9"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000170140.36633.8f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:11:59Z","timestamp":1715530319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000170140.36633.8f"}},"subtitle":["Direct Comparison of Brain Natriuretic Peptide (BNP) and N-Terminal Pro-BNP"],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1161\/01.HYP.0000170140.36633.8f"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000170140.36633.8f","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"2004-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}