{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:35:05Z","timestamp":1791275705068,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    Single nucleotide polymorphisms (SNPs) in genes encoding or influencing renal sodium transport systems were investigated as potential predictors of blood pressure (BP) response to a thiazide diuretic. A sample of 585 adults with essential hypertension (30 to 59.9 years of age; 50% blacks; 47% women) were treated with hydrochlorothiazide for 4 weeks (25 mg daily, orally) to determine office BP responses. Ambulatory BP responses were measured in a subset of 228 subjects. After adjustment for ethnicity, sex, age, and waist-to-hip ratio, 3 SNPs in\n                    <jats:italic>WNK1<\/jats:italic>\n                    (rs2107614, rs2277869, and rs1159744), encoding a lysine-deficient protein kinase that regulates thiazide-sensitive sodium-potassium cotransport, made statistically significant contributions to predicting ambulatory BP responses, accounting for 2% to 4% of variation in systolic and diastolic responses (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). SNPs in the \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoceptor (rs2400707) and the epithelial sodium channel \u03b3-subunit (rs5723 and rs5729) were associated with similar magnitude of variation in ambulatory systolic BP response (\n                    <jats:italic>P<\/jats:italic>\n                    =0.028) or office diastolic BP response (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05), respectively. However, SNPs evaluated in the furosemide-sensitive sodium-potassium chloride cotransporter, potassium inwardly rectifying channel, chloride channel, thiazide-sensitive sodium chloride cotransporter, epithelial sodium channel \u03b2-subunit, and the mineralocorticoid receptor were not associated with significant variation in ambulatory or office BP responses. Polymorphisms in genes regulating renal sodium transport, in particular\n                    <jats:italic>WNK1<\/jats:italic>\n                    , predict interindividual differences in antihypertensive responses to hydrochlorothiazide.\n                  <\/jats:p>","DOI":"10.1161\/01.hyp.0000186240.81996.57","type":"journal-article","created":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T20:33:49Z","timestamp":1127162029000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":71,"title":["<i>WNK1<\/i>\n                    Kinase Polymorphism and Blood Pressure Response to a Thiazide Diuretic"],"prefix":"10.1161","volume":"46","author":[{"given":"Stephen T.","family":"Turner","sequence":"first","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn (G.L.S., S.T.T.); Renal Division, Emory University, Atlanta, Ga (A.B.C.); and Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Sciences Center, Houston (E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn (G.L.S., S.T.T.); Renal Division, Emory University, Atlanta, Ga (A.B.C.); and Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Sciences Center, Houston (E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene B.","family":"Chapman","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn (G.L.S., S.T.T.); Renal Division, Emory University, Atlanta, Ga (A.B.C.); and Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Sciences Center, Houston (E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boerwinkle","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn (G.L.S., S.T.T.); Renal Division, Emory University, Atlanta, Ga (A.B.C.); and Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Sciences Center, Houston (E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00241-0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.37.2.739"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00624.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500215"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01029-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00200.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.2.182"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/379378"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(03)01011-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.3039"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.13.1168"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062844"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17443"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200409000-00012"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2002.00965.x"},{"key":"e_1_3_2_16_2","first-page":"389","volume":"18","year":"2005","unstructured":"Finkielman JD, Schwartz GL, Chapman AB, Boerwinkle E, Turner ST. Lack of agreement between office in ambulatory blood pressure responses to hydrochlorothiazide. Am J Hypertens. 2005; 18: 389\u2013402.","journal-title":"Am J Hypertens"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440420033005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.34.3.466"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200102000-00022"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.12.3.223"}],"updated-by":[{"DOI":"10.1161\/01.hyp.0000200782.88587.19","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2006,1,3]],"date-time":"2006-01-03T00:00:00Z","timestamp":1136246400000}}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000186240.81996.57","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T12:26:17Z","timestamp":1715516777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000186240.81996.57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1161\/01.HYP.0000186240.81996.57"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000186240.81996.57","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1028492.342140","asserted-by":"object"}]},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]},"assertion":[{"value":"2005-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}