{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:48:27Z","timestamp":1793969307738,"version":"4.8.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>\n                    Prolonged electrocardiographic QRS duration is frequently observed in congestive heart failure (CHF) patients. We hypothesized that CHF risk increases with longer QRS interval in individuals free of CHF. We evaluated 1759 Framingham Study participants (mean age, 69 years; 63% women) without prior myocardial infarction or CHF who attended a routine examination. QRS duration was analyzed as a continuous (log-transformed) and a categorical variable [referent, &lt;100 ms; incomplete bundle branch block (BBB), 100 to 119 ms; complete BBB, \u2265120 ms]. During follow-up (mean, 12.7 years), 324 participants (205 women) developed CHF. CHF incidence increased across the 3 baseline QRS duration categories in both sexes. Each SD increment in log-QRS duration was associated with a multivariable-adjusted 23% increase in CHF risk [95% confidence interval [CI] 8% to 38%;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001]. In time- dependent models with QRS category and risk factors updated every 2 years, incomplete BBB was associated with a 1.4-fold (95% CI, 1.05 to 1.96;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.03) and complete BBB with a 1.7-fold (95% CI, 1.28 to 2.35;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001) risk of CHF. These associations were maintained on adjustment for baseline left ventricular mass. In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk.\n                  <\/jats:p>","DOI":"10.1161\/01.hyp.0000217141.20163.23","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T20:34:23Z","timestamp":1144096463000},"page":"861-867","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Electrocardiographic QRS Duration and the Risk of Congestive Heart Failure"],"prefix":"10.1161","volume":"47","author":[{"given":"Ravi","family":"Dhingra","sequence":"first","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Pencina","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Ho","family":"Nam","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levy","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Larson","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Kannel","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Sr","given":"Ralph B.","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study (R.D., M.J.P., T.J.W., B.N., E.J.B., D.L., M.G.L., W.B.K., R.B.D., R.S.V.), National Heart, Lung, and Blood Institute, Framingham, Mass; Massachusetts Veterans Epidemiology Research and Information Center (R.D.), VA Boston Healthcare System and the Division of Aging, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass; Division of Cardiology (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Department of Mathematics and Statistics (M.J.P., B.N., M.G.L., R.B.D.), Boston University, Boston, Mass; Cardiology Section (R.S.V., E.J.B.) and Department of Preventive Medicine and Epidemiology (E.J.B., D.L., M.G.L., W.B.K., R.S.V.), Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.053"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.22.2494"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.046"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.6.730"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065226.24159.E9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90196-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00713-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00371-V"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200110000-00025"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00242-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1567"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.41.3.279"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197112232852601"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.3.607"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(72)90043-2"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80335-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.10.1252"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.69.2.166"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/096228029500400302"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00005"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.17.2118"},{"key":"e_1_3_2_26_2","unstructured":"SAS Institute Inc. SAS\/STAT User\u2019s Guide Version 6.12. Cary NC: SAS Institute Inc 1997: 871\u2013948."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00337-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.6.443"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800503"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00299-0"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000217141.20163.23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:17:55Z","timestamp":1761675475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000217141.20163.23"}},"subtitle":["The Framingham Heart Study"],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1161\/01.HYP.0000217141.20163.23"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000217141.20163.23","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"2006-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-02-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}