{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:14:48Z","timestamp":1715537688402},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p>Primary aldosteronism is an uncommon cause of hypertension but one of particular interest because of its distinctive pathophysiological mechanism of blood pressure elevation. Aldosterone has been associated with increased Na+,K+-adenosine triphosphatase (ATPase) activity, but there is controversy over which sodium transport parameters are responsible for this increase. We measured intracellular sodium, ouabain-sensitive and ouabain-insensitive sodium efflux, and the number of Na+,K+-ATPase sites of washed erythrocytes, as well as Na+-Li+ countertransport and the Li+-K+ cotransport rate constant of lithium-loaded red blood cells (RBCs) in six patients with primary aldosteronism and in 50 normal subjects. Ouabain-sensitive sodium efflux was significantly (p less than 0.001) higher for the primary aldosteronism patients than for normal subjects (1.85 +\/- 0.29 vs 1.51 +\/- 0.21 mmol\/L RBC\/hr) even though the intracellular sodium concentration (7.2 +\/- 1.5 vs 6.7 +\/- 1.9 mM) and the number of the Na+,K+-ATPase sites per RBC (331 +\/- 52 vs 385 +\/- 97) were not increased. The elevated sodium efflux appeared to be due to a significant (p less than 0.001) increase in the rate constant (1.60 +\/- 0.12 x 10(-15) vs 1.28 +\/- 0.15 x 10(-15) mmol\/site\/hr) of the ouabain-sensitive sodium efflux. The rate constant decreased significantly (p less than 0.01) after treatment.<\/jats:p>","DOI":"10.1161\/01.hyp.11.2.141","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:23:24Z","timestamp":1339460604000},"page":"141-146","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Sodium transport parameters in erythrocytes of patients with primary aldosteronism."],"prefix":"10.1161","volume":"11","author":[{"given":"J B","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N S","family":"Fineberg","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M H","family":"Weinberger","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.11.2.141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:29:45Z","timestamp":1715534985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.11.2.141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["10.1161\/01.HYP.11.2.141"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.11.2.141","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]},"assertion":[{"value":"1988-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}