{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:05:33Z","timestamp":1715558733706},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>The role of endogenous vasopressin in cardiovascular homeostasis was examined using vasopressin-deficient rats (Brattleboro) (n = 194) and their parent strain, Long-Evans rats (n = 181). Mean arterial pressure (blood pressure) and heart rate were measured every 4 seconds with or without infusion of drug solution for 21 hours, and mean values and their standard deviations (lability) were calculated. Blood pressure in Brattleboro rats (116 +\/- 1.1 mm Hg, mean +\/- SEM) was significantly higher than that in Long-Evans rats (96 +\/- 0.7 mm Hg, p less than 0.001), whereas heart rates (381 +\/- 3.3 and 375 +\/- 2.9 beats\/min, respectively) were similar. The lability of blood pressure and heart rate in Brattleboro rats (9.2 +\/- 0.1 mm Hg and 42.3 +\/- 0.7 beats\/min) was also greater than that in Long-Evans rats (6.7 +\/- 0.1 mm Hg, p less than 0.001 and 38.4 +\/- 0.8 beats\/min, p less than 0.01, respectively). In Brattleboro rats, intravenous vasopressin (0.1 ng\/kg\/min or 0.6 ng\/kg\/min) did not affect blood pressure, although it did reduce heart rate and decreased lability of blood pressure and heart rate. Intracerebroventricular (central) infusion of vasopressin (2 pg\/kg\/min) in Brattleboro rats induced initial hypertension and tachycardia followed by long-lasting hypotension and bradycardia, whereas in Long-Evans rats it induced only hypertension and tachycardia. In both strains, central vasopressin dramatically decreased the lability of blood pressure and heart rate. Neither intravenous (0.2 ng\/kg\/min) nor central desmopressin (2 pg\/kg\/min or 0.2 ng\/kg\/min), a V2 renal receptor agonist, changed any of these parameters in Brattleboro rats, although both diminished urinary volume. Neither intravenous (50 ng\/kg\/min) nor central (3.3 pg\/kg\/min) d(CH2)5-Tyr(Me)-arginine vasopressin, a vasopressin V1 receptor antagonist, modulated any of these parameters in Long-Evans rats. These results suggest that endogenous as well as exogenous vasopressin acts centrally as a cardiovascular inhibitor and stabilizer through a receptor mechanism other than V1 or V2 receptor mechanisms.<\/jats:p>","DOI":"10.1161\/01.hyp.15.3.291","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:23:24Z","timestamp":1339460604000},"page":"291-300","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiovascular depression and stabilization by central vasopressin in rats."],"prefix":"10.1161","volume":"15","author":[{"given":"Y","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nobunaga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sekino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.15.3.291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:22:25Z","timestamp":1715534545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.15.3.291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1161\/01.HYP.15.3.291"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.15.3.291","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]},"assertion":[{"value":"1990-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}