{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:49:07Z","timestamp":1759481347037},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>Metabolic acidosis has recently been observed in rat models of salt-sensitive genetic hypertension. To test the hypothesis that salt sensitivity in humans may be associated with abnormal acid-base homeostasis, we performed arterial blood gas analyses in young (20-31 years old) normotensive subjects (n = 40) who were placed on a low salt diet (20 mmol NaCl\/day) for 2 weeks with either 200 mmol sodium chloride or placebo added to the low salt diet for 1 week each in a randomized, single-blind crossover order. Furthermore, a subset of the subjects (seven salt-sensitive and eight salt-resistant) received 200 mmol sodium\/day as the citrate salt as a supplement to the low salt diet for a third week. During each regimen, blood pressure as well as arterial pH and bicarbonate levels were measured. Salt sensitivity was defined as a significant drop in mean arterial pressure greater than 3 mm Hg (mean of 30 readings taken during each diet, p less than 0.05) while the subject was on the low salt diet. According to this definition, 16 subjects were salt-sensitive and 24 salt-resistant. During the high sodium chloride regimen, arterial pH and bicarbonate levels were significantly lower in the salt-sensitive than in the salt-resistant group (p less than 0.0001). The increase in blood pressure caused by sodium chloride correlated inversely to the arterial pH (r = -0.57, p = 0.0002) and bicarbonate levels (r = -0.52, p = 0.0007) during the high salt diet. Sodium chloride increased mean arterial blood pressure in the salt-sensitive subjects; sodium citrate did not. Sodium citrate led to an increase in pH and bicarbonate levels in both groups. Our finding that a sodium chloride-induced rise in blood pressure is associated with lower arterial plasma pH and bicarbonate levels points to an abnormality in renal acid-base regulation in salt-sensitive subjects.<\/jats:p>","DOI":"10.1161\/01.hyp.16.4.407","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:23:24Z","timestamp":1339460604000},"page":"407-413","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Salt sensitivity in humans is associated with abnormal acid-base regulation."],"prefix":"10.1161","volume":"16","author":[{"given":"A M","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine and Nephrology, Universit\u00e4tsklinikum Steglitz, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kribben","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Nephrology, Universit\u00e4tsklinikum Steglitz, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Schattenfroh","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Nephrology, Universit\u00e4tsklinikum Steglitz, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cetto","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Nephrology, Universit\u00e4tsklinikum Steglitz, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Distler","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Nephrology, Universit\u00e4tsklinikum Steglitz, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.16.4.407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:38:50Z","timestamp":1715535530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.16.4.407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1161\/01.HYP.16.4.407"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.16.4.407","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]},"assertion":[{"value":"1990-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}