{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:15:32Z","timestamp":1715537732827},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>Active and inactive kallikrein or a kallikrein-like enzyme are found in the aorta, vena cava, and tail artery and veins of the rat. We studied the concentration of vascular kininogenase in rats with one-kidney, one clip renovascular hypertension and in unilaterally nephrectomized normotensive rats. Six weeks after surgery, active and total vascular kininogenase activity (active plus trypsin-activated) was measured. Blood pressure was 212 +\/- 4 mm Hg in the hypertensive rats (n = 33) and 120 +\/- 1 mm Hg in the normotensive rats (n = 32) (p less than 0.001). Active kininogenase was lower in the hypertensive rats; although the difference was not significant in the thoracic aorta (56 +\/- 8 versus 77 +\/- 15), it was highly significant in the abdominal aorta (63 +\/- 13 versus 167 +\/- 17, p less than 0.001) and tail artery (48 +\/- 8 versus 197 +\/- 31, p less than 0.003). Total vascular kininogenase activity (active plus trypsin-activated) was lower in the hypertensive rats in all arteries examined: thoracic aorta (183 +\/- 16 versus 380 +\/- 38, p less than 0.003), abdominal aorta (565 +\/- 61 versus 1,093 +\/- 74, p less than 0.001), and tail artery (532 +\/- 112 versus 1,243 +\/- 135, p less than 0.003). Active kininogenase in the vena cava was higher in the hypertensive rats (213 +\/- 56 versus 131 +\/- 31); however, this difference was not statistically significant, whereas in the tail veins it was highly significant (1,803 +\/- 221 versus 771 +\/- 79, p less than 0.003).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.16.4.436","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:23:24Z","timestamp":1339460604000},"page":"436-440","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["A kallikrein-like enzyme in blood vessels of one-kidney, one clip hypertensive rats."],"prefix":"10.1161","volume":"16","author":[{"given":"H","family":"Nolly","sequence":"first","affiliation":[{"name":"Hypertension Research Division, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O A","family":"Carretero","sequence":"additional","affiliation":[{"name":"Hypertension Research Division, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Scicli","sequence":"additional","affiliation":[{"name":"Hypertension Research Division, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Madeddu","sequence":"additional","affiliation":[{"name":"Hypertension Research Division, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Scicli","sequence":"additional","affiliation":[{"name":"Hypertension Research Division, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.16.4.436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:38:55Z","timestamp":1715535535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.16.4.436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1161\/01.HYP.16.4.436"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.16.4.436","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]},"assertion":[{"value":"1990-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}