{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:54:07Z","timestamp":1760385247805},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4_supplement","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:p>To determine the importance of angiotensin converting enzyme (ACE) activity in the development of arterial proliferative lesions in a primate model, the response to vascular injury was studied in five baboons treated with oral cilazapril (20 mg\/kg\/day) and in five untreated control animals. Each animal underwent three procedures: 1) carotid artery endarterectomy, 2) balloon catheter deendothelialization of the superficial femoral artery, and 3) surgical placement of bilateral aorto-iliac expanded polytetrafluoroethylene (Gore-Tex) vascular grafts. Cilazapril therapy was initiated 1 week preoperatively and continued throughout the study interval. At 1 and 3 weeks postoperatively, plasma ACE activity was inhibited by more than 96% versus control values. After animals were killed at 3 months, injured vessel and graft segments were evaluated morphometrically. Although the response between animals was variable, average cross-sectional areas of neointima did not differ between the cilazapril-treated and control groups at sites of carotid endarterectomy (0.26 +\/- 0.12 versus 0.34 +\/- 0.17 mm2, respectively; p greater than 0.5), femoral artery ballooning (0.15 +\/- 0.08 versus 0.11 +\/- 0.01 mm2; p greater than 0.5), or at graft anastomoses (1.86 +\/- 0.50 versus 1.72 +\/- 0.50 mm2; p greater than 0.5). Thus, cilazapril did not reduce intimal thickening over 3 months in these primate arterial injury models. However, a possible beneficial effect of cilazapril, which might be apparent at earlier time points or with larger animal groups, cannot be excluded.<\/jats:p>","DOI":"10.1161\/01.hyp.18.4_suppl.ii70","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T23:30:52Z","timestamp":1343863852000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon."],"prefix":"10.1161","volume":"18","author":[{"given":"S R","family":"Hanson","sequence":"first","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Dodson","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lumsden","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A B","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Clowes","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L A","family":"Harker","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology-Oncology), Emory University Atlanta, Ga. 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:35:30Z","timestamp":1715535330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.18.4_Suppl.II70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":0,"journal-issue":{"issue":"4_supplement","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1161\/01.HYP.18.4_Suppl.II70"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.18.4_suppl.ii70","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]},"assertion":[{"value":"1991-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}