{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T23:36:59Z","timestamp":1719272219215},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6_pt_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p>To evaluate whether, in the forearm of hypertensive patients with different circulating renin profiles, local beta-adrenergic receptor-induced production of active renin, plasma renin activity, angiotensin I (Ang I), and angiotensin II (Ang II) was or was not related to the renin profile, we studied four groups of patients: 1) hypertensive patients with primary aldosteronism and suppressed circulating plasma renin activity values (0.15 +\/- 0.1 ng Ang I\/mL per hour; n = 7), 2) essential hypertensive patients with low (0.47 +\/- 0.1 ng Ang I\/mL per hour; n = 8) circulating plasma renin activity values, 3) essential hypertensive patients with normal (2.48 +\/- 0.52 ng Ang I\/mL per hour; n = 8) circulating plasma renin activity value, and 4) renovascular hypertensive patients with high circulating plasma renin activity values (4.16 +\/- 2.1 ng Ang I\/mL per hour; n = 10). Isoproterenol was infused into the brachial artery, and active renin, plasma renin activity, and Ang I and Ang II forearm balance (venous-arterial differences corrected for forearm blood flow by strain-gauge plethysmography) were measured. Despite a comparable vasodilation, beta-adrenergic stimulation failed to release active renin, plasma renin activity, and Ang I and Ang II in primary aldosteronism. It slightly increased them (except for Ang I) in low renin patients but determined a local production in normal renin and renovascular hypertensive patients. The individual increments in plasma renin activity and Ang II release induced by isoproterenol showed a correlation with the renin profile.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.21.6.852","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"852-860","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Indirect evidence for vascular uptake of circulating renin in hypertensive patients."],"prefix":"10.1161","volume":"21","author":[{"given":"S","family":"Taddei","sequence":"first","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Virdis","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Abdel-Haq","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Giovannetti","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Duranti","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Arena","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Favilla","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Salvetti","sequence":"additional","affiliation":[{"name":"I Clinica Medica, University of Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.21.6.852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:40:05Z","timestamp":1715535605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.21.6.852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":0,"journal-issue":{"issue":"6_pt_1","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1161\/01.HYP.21.6.852"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.21.6.852","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]},"assertion":[{"value":"1993-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}