{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:53:20Z","timestamp":1761155600676},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>Abnormal regulation of local vascular tone occurs early in human and experimental atherosclerosis. Impaired endothelium-dependent vascular relaxations mediated by endothelium-derived relaxing factor are an important contributor to these abnormalities. Endothelium-derived relaxing factor is nitric oxide released as such or attached to a carrier molecule. Oxidized lipoproteins impede endothelium-derived relaxing factor-mediated responses in vitro. We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction. Vitamin E and selenium deficiencies were induced in a group of hypertension-prone Dahl salt-sensitive rats fed a diet high in cholesterol (4%) but low in NaCl (0.5%) for 18 weeks. Two other groups of Dahl salt-sensitive rats received diets sufficient in vitamin E and selenium but containing either high or normal cholesterol levels (control group). Serum cholesterol levels increased approximately 10-fold in the two groups of rats fed high-cholesterol diets. Systolic blood pressure was 143 +\/- 3 mm Hg in high-cholesterol\/vitamin E- and selenium-sufficient rats and 142 +\/- 5 mm Hg in high-cholesterol\/vitamin E- and selenium-deficient rats (P = NS). Mild intimal thickening and occasional mononuclear cell infiltration were observed in both of these groups. Serum vitamin E levels were decreased, whereas serum thiobarbituric acid-reactive substances and exhaled pentane (two indicators of endogenous lipid oxidation) were significantly increased in high-cholesterol\/vitamin E- and selenium-deficient rats compared with high-cholesterol\/vitamin E- and selenium-sufficient rats.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.22.1.56","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"56-61","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats."],"prefix":"10.1161","volume":"22","author":[{"given":"L","family":"Raij","sequence":"first","affiliation":[{"name":"Medical Research Service, Veterans Affairs Medical Center, Minneapolis, MN 55417."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Nagy","sequence":"additional","affiliation":[{"name":"Medical Research Service, Veterans Affairs Medical Center, Minneapolis, MN 55417."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Coffee","sequence":"additional","affiliation":[{"name":"Medical Research Service, Veterans Affairs Medical Center, Minneapolis, MN 55417."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E G","family":"DeMaster","sequence":"additional","affiliation":[{"name":"Medical Research Service, Veterans Affairs Medical Center, Minneapolis, MN 55417."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.22.1.56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:21:49Z","timestamp":1715534509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.22.1.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1161\/01.HYP.22.1.56"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.22.1.56","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]},"assertion":[{"value":"1993-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}