{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:08:57Z","timestamp":1761059337342},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>The current study was undertaken to define a biological role for the endothelin-A receptor in a clinically relevant model of altered systemic and renal function produced by suprarenal aortic cross-clamping. This model is associated with profound systemic and renal vasoconstriction, acute renal failure, and a significant increase in circulating endothelin. Studies were performed in three groups of anesthetized mongrel dogs. Group 1 (n = 5) underwent aortic cross-clamping for 1 hour; group 2 (n = 5) underwent aortic cross-clamping for 1 hour in the presence of BQ-123, a specific antagonist of the endothelin-A receptor; group 3 (n = 4) received BQ-123 alone. The marked systemic and renal vasoconstriction associated with aortic cross-clamping in group 1 was markedly attenuated in group 2 in the presence of BQ-123. Unlike the vasoconstrictor response, BQ-123 did not attenuate the decrease in glomerular filtration rate associated with this model. Under unstimulated conditions in group 3, BQ-123 had no actions on systemic or renal hemodynamics. In conclusion, the current study demonstrates that the systemic and renal vasoconstriction associated with aortic cross-clamping are in part mediated through the interaction of endothelin and the endothelin-A receptor. This study demonstrates the functional importance of increased endogenous endothelin in the regulation of vascular tone in this pathophysiological state.<\/jats:p>","DOI":"10.1161\/01.hyp.22.1.62","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"62-66","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Biological role for the endothelin-A receptor in aortic cross-clamping."],"prefix":"10.1161","volume":"22","author":[{"given":"A J","family":"Stingo","sequence":"first","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Clavell","sequence":"additional","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L L","family":"Aarhus","sequence":"additional","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J C","family":"Burnett","sequence":"additional","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.22.1.62","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:21:38Z","timestamp":1715534498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.22.1.62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1161\/01.HYP.22.1.62"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.22.1.62","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]},"assertion":[{"value":"1993-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}