{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:31:44Z","timestamp":1759483904148},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>In two-kidney, one clip (2K1C) renovascular hypertension, blood flow is reduced to the clipped but not to the nonclipped kidney, despite elevated angiotensin II. To determine possible interactions between endothelium-derived nitric oxide and angiotensin, we studied bilateral renal blood flow using radioactive microspheres in anesthetized 2K1C hypertensive rats 4 weeks after clipping. We studied the response to nitric oxide synthesis inhibition with 10 mg\/kg body wt NG-nitro-L-arginine- methyl ester (L-NAME) in hypertensive rats untreated (n = 5) or treated (n = 5) with 10 mg\/kg body wt of the angiotensin II antagonist losartan. 2K1C rats had a blood pressure of 159 +\/- 9 mm Hg, and renal blood flow to the clipped kidney was reduced 87% compared with the nonclipped kidney. L-NAME increased blood pressure 36 +\/- 5 mm Hg and decreased renal blood flow in the nonclipped kidney 61% (4.9 +\/- 0.5 to 1.9 +\/- 0.4 mL\/min per gram kidney weight, P &lt; .001). Renal vascular resistance increased 200% (33.4 +\/- 2.2 to 100.7 +\/- 15.0 resistance units [RU], P &lt; .005). Renal blood flow and resistance in the clipped kidney were unchanged by L-NAME. Treatment of 2K1C rats with losartan reduced blood pressure (154 +\/- 8 to 116 +\/- 11 mm Hg, P &lt; .01), did not change blood flow in the nonclipped, but normalized it in the clipped kidney (4.8 +\/- 0.8 mL\/min per gram kidney weight).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.22.2.237","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"237-242","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Renal nitric oxide and angiotensin II interaction in renovascular hypertension."],"prefix":"10.1161","volume":"22","author":[{"given":"D H","family":"Sigmon","sequence":"first","affiliation":[{"name":"Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich. 48202-2689."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H","family":"Beierwaltes","sequence":"additional","affiliation":[{"name":"Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich. 48202-2689."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.22.2.237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:23:13Z","timestamp":1715534593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.22.2.237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1161\/01.HYP.22.2.237"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.22.2.237","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]},"assertion":[{"value":"1993-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}