{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:40:03Z","timestamp":1773736803663,"version":"3.50.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:p>Phase I of the Trials of Hypertension Prevention was a multicenter, randomized trial of the feasibility and efficacy of seven nonpharmacologic interventions, including sodium reduction, in lowering blood pressure in 30- to 54-year-old individuals with a diastolic blood pressure of 80 to 89 mm Hg. Six centers tested an intervention designed to reduce dietary sodium to 80 mmol (1800 mg)\/24 h with a total of 327 active intervention and 417 control subjects. The intervention consisted of eight group and two one-to-one meetings during the first 3 months, followed by less-intensive counseling and support for the duration of the study. The mean net decrease in sodium excretion was 43.9 mmol\/24 h at 18 months. Women had lower sodium intake at baseline and were therefore more likely to decrease to less than 80 mmol\/24 h. Black subjects were less likely to decrease to less than 80 mmol\/d, independent of sex or baseline sodium excretion. The mean (95% confidence interval) net decrease associated with treatment was -2.1 (-3.3, -0.8) mm Hg for systolic blood pressure and -1.2 (-2.0, -0.3) mm Hg for diastolic blood pressure at 18 months (both P &lt; .01). Multivariate analyses indicated a larger systolic blood pressure effect in women (-4.44 versus -1.23 mm Hg in men), adjusted for age, race, baseline blood pressure, and baseline 24-hour urinary sodium excretion (P = .02). Dose-response analyses indicated an adjusted decrease of -1.4 mm Hg for systolic blood pressure and -0.9 mm Hg for diastolic blood pressure for a decrease of 100 mmol\/24 h in 18-month sodium excretion. These results support the utility of sodium reduction as a population strategy for hypertension prevention and raise questions about possible differences in dose response associated with gender and initial level of sodium intake.<\/jats:p>","DOI":"10.1161\/01.hyp.22.4.502","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"502-512","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Feasibility and efficacy of sodium reduction in the Trials of Hypertension Prevention, phase I. Trials of Hypertension Prevention Collaborative Research Group."],"prefix":"10.1161","volume":"22","author":[{"given":"S K","family":"Kumanyika","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R","family":"Hebert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Cutler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V I","family":"Lasser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"Sugars","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Steffen-Batey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A A","family":"Brewer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L D","family":"Shepek","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N R","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.22.4.502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:18:03Z","timestamp":1715534283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.22.4.502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1161\/01.HYP.22.4.502"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.22.4.502","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]},"assertion":[{"value":"1993-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}