{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:33:07Z","timestamp":1759483987943},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:p>Reduced extracellular pH and bicarbonate levels recently have been reported in normotensive salt-sensitive subjects. To assess the possible role of altered renal acid-base handling in the perturbation of acid-base status in these individuals, we measured the renal acid-base excretion after an acute oral administration of either an alkali or acid load in normotensive salt-sensitive and salt-resistant men. Twenty-four young (22 to 29 years old), healthy male volunteers were placed on a low-salt diet (20 mmol NaCl per day) for 2 weeks with either 220 mmol NaCl or placebo added to the low-salt diet for 1 week each in a randomized single-blind crossover order. Salt sensitivity was defined as a significant drop in mean arterial pressure (&gt; 3 mm Hg, mean of 60 readings taken on the seventh day of each diet, P &lt; .05) during the low-salt diet. On the fifth and seventh days of each week, subjects were given an oral load of either sodium citrate (0.7 mmol\/kg) or ammonium chloride (2.2 mmol\/kg), respectively, in a randomized order, and arterial and urinary acid-base status was assessed at baseline and followed for 8 hours thereafter. According to the above definition, 13 subjects were considered salt sensitive. During the high-salt diet, mean arterial pressure was higher in the salt-sensitive than in the salt-resistant group (P &lt; .01). Cumulative urinary bicarbonate excretion after the administration of sodium citrate was lower in the salt-sensitive than in the salt-resistant subjects during both the low-salt (46%, P &lt; .001) and high-salt (32%, P &lt; .01) diets.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.22.6.884","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"884-890","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Renal acid-base excretion in normotensive salt-sensitive humans."],"prefix":"10.1161","volume":"22","author":[{"given":"A M","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cetto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Schorr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K P","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Distler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Free University of Berlin, FRG."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.22.6.884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:27:15Z","timestamp":1715534835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.22.6.884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,12]]}},"alternative-id":["10.1161\/01.HYP.22.6.884"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.22.6.884","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,12]]},"assertion":[{"value":"1993-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}