{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:58:09Z","timestamp":1778273889645,"version":"3.51.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6_pt_2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>In anesthetized rats we examined whether calcitonin gene-related peptide activated renal pelvic sensory receptors and, if so, whether activation of renal pelvic calcitonin gene-related peptide receptors contributes to the inhibitory renorenal reflex response to renal mechanoreceptor stimulation. Calcitonin gene-related peptide (0.0026, 0.026, 0.26, and 2.6 mumol\/L) administered into the renal pelvis increased ipsilateral afferent renal nerve activity in a concentration-dependent fashion (32 +\/- 14%, 69 +\/- 19%, 93 +\/- 26%, and 253 +\/- 48% [all P &lt; .01], respectively). The increases in ipsilateral afferent renal nerve activity elicited by calcitonin gene-related peptide were associated with increases in contralateral urinary sodium excretion. The calcitonin gene-related peptide receptor antagonist human CGRP (h-CGRP) (8-37) (0.01, 0.1, 1.0, and 10 mumol\/L) decreased the ipsilateral afferent renal nerve activity response to renal pelvic administration of calcitonin gene-related peptide (0.26 mumol\/L) in a concentration-dependent fashion (29 +\/- 4%, 33 +\/- 12%, 76 +\/- 9% [P &lt; .01], and 86 +\/- 13% [P &lt; .01], respectively). In the presence of renal pelvic perfusion with vehicle, an increase in ureteral pressure of 5, 10, and 20 mm Hg increased ipsilateral afferent renal nerve activity by 13 +\/- 7%, 41 +\/- 7% (P &lt; .01), and 95 +\/- 15% (P &lt; .01) and contralateral urinary sodium excretion by 8 +\/- 1%, 24 +\/- 4%, and 42 +\/- 7% (all P &lt; .05). The ipsilateral afferent renal nerve activity and contralateral natriuretic responses to graded increases in ureteral pressure (5 to 20 mm Hg) were unaltered by renal pelvic perfusion with h-CGRP (8-37) at 1.0 and 10 mumol\/L.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.23.6.1063","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"1063-1067","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Renal sensory receptor activation by calcitonin gene-related peptide."],"prefix":"10.1161","volume":"23","author":[{"given":"J R","family":"Gontijo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U C","family":"Kopp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.23.6.1063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:43:02Z","timestamp":1715535782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.23.6.1063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":0,"journal-issue":{"issue":"6_pt_2","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1161\/01.HYP.23.6.1063"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.23.6.1063","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]},"assertion":[{"value":"1994-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}