{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:28:33Z","timestamp":1780453713755,"version":"3.54.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6_pt_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>We studied the contribution of vasopressin to the maintenance of high blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertension in the rat using the nonpeptide orally effective vasopressin V1 receptor antagonist OPC-21268. Binding kinetic studies demonstrated that oral OPC-21268 (30 mg\/kg) acted as a competitive antagonist at the vasopressin V1 receptor in DOCA-salt and salt control rats. Basal mean intra-arterial blood pressure was 140 +\/- 4 mm Hg (n = 12) in DOCA-salt rats compared with 111 +\/- 2 mm Hg in salt control rats (n = 18). Acute oral OPC-21268 (30 mg\/kg) significantly (P &lt; .01) reduced mean intra-arterial pressure in DOCA-salt hypertension, with an average maximal decrease of 24 +\/- 3 mm Hg occurring at 2.5 +\/- 0.7 hours after dosing. Systolic blood pressure (tail-cuff) in DOCA-salt rats was 178 +\/- 2 mm Hg. Chronic oral OPC-21268 (30 mg\/kg) twice daily for 7 days significantly (P &lt; .01) reduced systolic blood pressure in DOCA-salt hypertension, with an average maximal decrease of 27 +\/- 5 mm Hg. The antihypertensive effect was reversed 5 days after treatment with OPC-21268 was stopped. In water control rats basal systolic pressure (120 +\/- 1 mm Hg, n = 20) was unchanged by chronic oral OPC-21268 (30 mg\/kg twice daily for 7 days), and this was confirmed by direct measurement of mean intra-arterial pressure. After chronic oral OPC-21268 (30 mg\/kg twice daily for 7 days) hepatic V1 receptor binding was significantly reduced for up to 10 hours (P &lt; .05).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.hyp.23.6.737","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"737-743","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Blood pressure-lowering effect of an orally active vasopressin V1 receptor antagonist in mineralocorticoid hypertension in the rat."],"prefix":"10.1161","volume":"23","author":[{"given":"L M","family":"Burrell","sequence":"first","affiliation":[{"name":"University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Phillips","sequence":"additional","affiliation":[{"name":"University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Stephenson","sequence":"additional","affiliation":[{"name":"University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Risvanis","sequence":"additional","affiliation":[{"name":"University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A","family":"Rolls","sequence":"additional","affiliation":[{"name":"University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C I","family":"Johnston","sequence":"additional","affiliation":[{"name":"University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.23.6.737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:09:23Z","timestamp":1715533763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.23.6.737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":0,"journal-issue":{"issue":"6_pt_1","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1161\/01.HYP.23.6.737"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.23.6.737","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]},"assertion":[{"value":"1994-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}