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In nine healthy humans an infusion of human amylin that resulted in steady state plasma amylin levels in the subnanomolar range led to significant increases in plasma renin and aldosterone concentrations. These changes occurred in the absence of significant changes in plasma electrolytes, catecholamines, vasopressin, total renin, or osmolality. Diastolic pressure at 30 minutes and plasma glucose at 60 minutes rose modestly. Since amylin has both metabolic and renal actions, this peptide may be an important link between hypertension, insulin resistance, and the renin-angiotensin system.<\/jats:p>","DOI":"10.1161\/01.hyp.26.3.460","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"460-464","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Amylin Stimulates Plasma Renin Concentration in Humans"],"prefix":"10.1161","volume":"26","author":[{"given":"Mark E.","family":"Cooper","sequence":"first","affiliation":[{"name":"From the Department of Medicine, University of Melbourne, Austin &amp; Repatriation Medical Centre, Heidelberg, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"McNally","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, University of Melbourne, Austin &amp; Repatriation Medical Centre, Heidelberg, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paddy A.","family":"Phillips","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, University of Melbourne, Austin &amp; Repatriation Medical Centre, Heidelberg, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin I.","family":"Johnston","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, University of Melbourne, Austin &amp; Repatriation Medical Centre, Heidelberg, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.12.1595"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111776"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91781-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91904-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430320205"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90081-T"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/335632a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90411-Z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92391-7"},{"key":"e_1_3_2_11_2","unstructured":"Wookey P Tikellis C Du HC Sexton P Young AA Gaela LSL Brickett KS Beaumont K Cooper ME. 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