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Changes in vascular function are characterized by preservation of smooth muscle relaxation, with the exception of activity of ATP-sensitive potassium channels, and dysfunction of endothelium. Regression of atherosclerosis, by treatment of hyperlipidemia, results in quite rapid removal of lipid from the vessel wall but with inconsistent improvement in maximal vasodilator capacity. In contrast, endothelial function improves during regression of atherosclerosis, and hyperresponsiveness to serotonin subsides rapidly. Effective treatment of hypertension produces regression of vascular hypertrophy, and some approaches (especially angiotensin-converting enzyme inhibitors) are effective in correcting vascular remodeling. Endothelium-dependent relaxation generally improves during antihypertensive treatment. Reduction in pulse pressure may be more important than reduction in mean arterial pressure in reversing the structural and functional abnormalities of hypertensive vessels.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.26.3.509","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"509-513","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Sick Vessel Syndrome"],"prefix":"10.1161","volume":"26","author":[{"given":"Donald D.","family":"Heistad","sequence":"first","affiliation":[{"name":"From the Departments of Internal Medicine, Pharmacology, and Pathology, Cardiovascular Center and Center on Aging, College of Medicine and Veterans Administration Medical Center, Iowa City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine, Pharmacology, and Pathology, Cardiovascular Center and Center on Aging, College of Medicine and Veterans Administration Medical Center, Iowa City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Baumbach","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine, Pharmacology, and Pathology, Cardiovascular Center and Center on Aging, College of Medicine and Veterans Administration Medical Center, Iowa City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M.","family":"Faraci","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine, Pharmacology, and Pathology, Cardiovascular Center and Center on Aging, College of Medicine and Veterans Administration Medical Center, Iowa City."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.5.8181171"},{"key":"e_1_3_2_2_2","first-page":"21","volume":"9","year":"1981","unstructured":"Bond MG, Adams MR, Bullock BC. 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