{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:14:41Z","timestamp":1762157681466,"version":"3.40.3"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:p><jats:italic>Abstract<\/jats:italic>Recent observations demonstrate the presence of neurosteroids and their rapid increase in response to acute stress. In view of a steroidal nature of ouabainlike compound, we tested the hypothesis that ouabainlike compound may participate in a homeostatic response to acute stress. Male Wistar rats were subjected to acute stress by swimming in water (22\u00b0C) for 10 minutes. The levels of ouabainlike compound in plasma, hypothalamus, pituitary, and adrenal at 10, 40, and 70 minutes (n=8 for each) after the end of swim stress were compared with nonstressed control levels (n=10). Ouabainlike compound was measured by a radioimmunoassay for ouabain. Plasma levels of corticosterone and catecholamines were also measured. Plasma corticosterone concentrations increased rapidly at 10 minutes (<jats:italic>P<\/jats:italic>&lt;.01) and then declined. A trend for a rise in plasma catecholamines was found at 10 minutes. Adrenal levels of ouabainlike compound concomitantly increased at 10 minutes (<jats:italic>P<\/jats:italic>&lt;.01, control: 58.9\u00b15.9 pmol ouabain equivalents per gram; 10 minutes: 92.5\u00b14.8; 40 minutes: 47.3\u00b19.6; 70 minutes: 45.1\u00b16.3). In contrast, the response of plasma ouabainlike compound was slow and doubled at 40 minutes (<jats:italic>P<\/jats:italic>&lt;.01, control: 115\u00b112 pmol ouabain equivalents per liter; 10 minutes: 132\u00b123; 40 minutes: 226\u00b153; 70 minutes: 117\u00b116). Ouabainlike compound levels in hypothalamus and pituitary remained unaltered. These findings suggest that ouabainlike compound may function as a stress hormone.<\/jats:p>","DOI":"10.1161\/01.hyp.26.6.1173","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:24:03Z","timestamp":1339460643000},"page":"1173-1176","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Stress-Induced Elevation of Ouabainlike Compound in Rat Plasma and Adrenal"],"prefix":"10.1161","volume":"26","author":[{"given":"Atsuo","family":"Goto","sequence":"first","affiliation":[{"name":"From the Second Department of Internal Medicine, University of Tokyo (A.G., H.N., M.O.); Department of Human Dry Dock, Sanraku Hospital (K.Y.); and Department of Physiology, Osaka City University (Y.T.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Yamada","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine, University of Tokyo (A.G., H.N., M.O.); Department of Human Dry Dock, Sanraku Hospital (K.Y.); and Department of Physiology, Osaka City University (Y.T.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagoshi","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine, University of Tokyo (A.G., H.N., M.O.); Department of Human Dry Dock, Sanraku Hospital (K.Y.); and Department of Physiology, Osaka City University (Y.T.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitake","family":"Terano","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine, University of Tokyo (A.G., H.N., M.O.); Department of Human Dry Dock, Sanraku Hospital (K.Y.); and Department of Physiology, Osaka City University (Y.T.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Omata","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine, University of Tokyo (A.G., H.N., M.O.); Department of Human Dry Dock, Sanraku Hospital (K.Y.); and Department of Physiology, Osaka City University (Y.T.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.3.658"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.6.C1367"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(76)90284-8"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0031-6997(25)00464-8","volume":"44","year":"1992","unstructured":"Goto A, Yamada K, Yagi N, Yoshioka M, Sugimoto T. Physiology and pharmacology of endogenous digitalis-like factors. Pharmacol Rev. 1992;44:377-399.","journal-title":"Pharmacol Rev"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","unstructured":"Hamlyn JM Manunta P. Ouabain digitalis-like factors and hypertension. J Hypertens. 1992;10(suppl 7):S99-S111.","DOI":"10.1097\/00004872-199212000-00012"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.14.6259"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.22.2.178"},{"key":"e_1_3_1_8_2","first-page":"569","volume":"12","year":"1994","unstructured":"Manunta P, Rogowski AC, Hamilton BP, Hamlyn JM. Ouabain-induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure. J Hypertens. 1994;12:569-576.","journal-title":"J Hypertens"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","unstructured":"Yamada K Goto A Nagoshi H Chen Hui Yagi N Sasabe M Omata M. Participation of ouabainlike compound in reduced renal mass\u2013saline hypertension. Hypertension. 1994;23(suppl I):I-110-I-113.","DOI":"10.1161\/01.HYP.23.1_Suppl.I110"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/7.7.591"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","unstructured":"Ludens JH Clark MA Kolbasa KP Hamlyn JM. Digitalis-like factor and ouabain-like compound in plasma of volume-expanded dogs. J Cardiovasc Pharmacol. 1993;22(suppl 2):S38-S41.","DOI":"10.1097\/00005344-199322002-00014"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6143403"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00078-N"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.71.5.1394869"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.6.1027"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.25.4.814"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(05)80006-9"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.10.4553"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1966.tb09873.x"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.266.5.C1357"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90437-0"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.6.1347506"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.5.632"},{"key":"e_1_3_1_24_2","first-page":"304","volume":"33","year":"1988","unstructured":"Rauch AL, Callahan MF, Buckalew VM Jr. Influence of stress on plasma and tissue levels of an endogenous ligand to the digitalis receptor. Kidney Int. 1988;33:304. Abstract.","journal-title":"Kidney Int"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90629-7"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.5.C1443"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.73.6.8222082"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.264.3.E413"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.2.8033829"},{"key":"e_1_3_1_30_2","first-page":"63","volume":"27","year":"1980","unstructured":"Yanagihara N. Stimulatory effect of ouabain on catecholamine synthesis in bovine adrenal medullary slices. Tokushima J Exp Med. 1980;27:63-68.","journal-title":"Tokushima J Exp Med"},{"key":"e_1_3_1_31_2","first-page":"1047","volume":"48","year":"1994","unstructured":"Yoshizumi M, Ishimura Y, Masuda Y, Houchi H, Kato I, Oka M. Inhibition by ouabain of palytoxin-induced catecholamine secretion and calcium influx into cultured bovine adrenal chromaffin cells. Biochem Pharmacol. 1994;48:1047-1049.","journal-title":"Biochem Pharmacol"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90466-G"},{"key":"e_1_3_1_33_2","first-page":"1413","volume":"25","year":"1995","unstructured":"Yamada K, Goto A, Nagoshi H, Terano Y, Omata M. Ouabainlike compound as a defensive factor against excessive body sodium. Hypertension. 1995;25:1413. Abstract.","journal-title":"Hypertension"},{"key":"e_1_3_1_34_2","unstructured":"Cayosa LB Hamilton BP Manunta P Hagen AS Laredo J Hamlyn JM. Effect of ACTH and angiotensin II on plasma ouabain. J Hypertens. 1994;12(suppl 3):S164. Abstract."},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90337-8"},{"key":"e_1_3_1_36_2","doi-asserted-by":"crossref","unstructured":"Graves SW Glatter KA Lazarus JM Williams GH Hollenberg NK. Volume expansion in renal failure patients: a paradigm for a clinically relevant [Na K]ATPase inhibitor. J Cardiovasc Pharmacol. 1993;22(suppl 2):S54-S57.","DOI":"10.1097\/00005344-199322002-00018"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.26.6.1173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T19:23:36Z","timestamp":1743362616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.26.6.1173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["10.1161\/01.HYP.26.6.1173"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.26.6.1173","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"type":"print","value":"0194-911X"},{"type":"electronic","value":"1524-4563"}],"subject":[],"published":{"date-parts":[[1995,12]]},"assertion":[{"value":"1995-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}