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In this study we investigated the cardiovascular effects of nitric oxide in the lateral ventricle, nucleus tractus solitarii, area postrema, and rostral ventrolateral medulla in urethane-anesthetized male Sprague-Dawley rats. Microinjection of<jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>-monomethyl-<jats:sc>l<\/jats:sc>-arginine, a nitric oxide synthase inhibitor, into the cerebral ventricle of rats elicited a dose-dependent increase in blood pressure and heart rate. This suggests that nitric oxide may be involved in central cardiovascular regulation. Unilateral microinjection (60 nL) of<jats:sc>l<\/jats:sc>-arginine (1 to 100 nmol) into the nucleus tractus solitarii and rostral ventrolateral medulla produced prominent dose-related depressor and bradycardic effects and reduced renal sympathetic nerve activity. However,<jats:sc>l<\/jats:sc>-arginine had no significant cardiovascular effects in the area postrema. In addition, 4 to 6 hours after intravenous injection of bacterial endotoxin-lipopolysaccharide (10 mg\/kg), there was a time-related potentiation of the<jats:sc>l<\/jats:sc>-arginine\u2013induced depressor and bradycardic effects in the nucleus tractus solitarii. These results indicate that nitric oxide is involved in central cardiovascular regulation. The depressor effect of nitric oxide in the nucleus tractus solitarii and rostral ventrolateral medulla may be through inhibition of renal sympathetic nerve activity.<\/jats:p>","DOI":"10.1161\/01.hyp.27.1.36","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":188,"title":["Cardiovascular Effects of Nitric Oxide in the Brain Stem Nuclei of Rats"],"prefix":"10.1161","volume":"27","author":[{"given":"Ching-Jiunn","family":"Tseng","sequence":"first","affiliation":[{"name":"From the Department of Medical Education and Research, Veterans General Hospital\u2013Kaohsiung (C.-J.T., L.-P.G.), and Departments of Pharmacology (C.-J.T., H.-Y.L., H.-C.L., M.-H.Y.) and Physiology and Biophysics (C.-S.T.), National Defense Medical Center, Taipei, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ya","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Medical Education and Research, Veterans General Hospital\u2013Kaohsiung (C.-J.T., L.-P.G.), and Departments of Pharmacology (C.-J.T., H.-Y.L., H.-C.L., M.-H.Y.) and Physiology and Biophysics (C.-S.T.), National Defense Medical Center, Taipei, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Medical Education and Research, Veterans General Hospital\u2013Kaohsiung (C.-J.T., L.-P.G.), and Departments of Pharmacology (C.-J.T., H.-Y.L., H.-C.L., M.-H.Y.) and Physiology and Biophysics (C.-S.T.), National Defense Medical Center, Taipei, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luo-Ping","family":"Ger","sequence":"additional","affiliation":[{"name":"From the Department of Medical Education and Research, Veterans General Hospital\u2013Kaohsiung (C.-J.T., L.-P.G.), and Departments of Pharmacology (C.-J.T., H.-Y.L., H.-C.L., M.-H.Y.) and Physiology and Biophysics (C.-S.T.), National Defense Medical Center, Taipei, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Se","family":"Tung","sequence":"additional","affiliation":[{"name":"From the Department of Medical Education and Research, Veterans General Hospital\u2013Kaohsiung (C.-J.T., L.-P.G.), and Departments of Pharmacology (C.-J.T., H.-Y.L., H.-C.L., M.-H.Y.) and Physiology and Biophysics (C.-S.T.), National Defense Medical Center, Taipei, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Hsiung","family":"Yen","sequence":"additional","affiliation":[{"name":"From the Department of Medical Education and Research, Veterans General Hospital\u2013Kaohsiung (C.-J.T., L.-P.G.), and Departments of Pharmacology (C.-J.T., H.-Y.L., H.-C.L., M.-H.Y.) and Physiology and Biophysics (C.-S.T.), National Defense Medical Center, Taipei, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.61.6.2890446"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.001135"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","year":"1991","unstructured":"Moncada S, Palmer RMJ, Higgs EA. 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