{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:58:04Z","timestamp":1761541084399,"version":"3.40.3"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p><jats:italic>Abstract<\/jats:italic>On the basis of evidence suggesting the activation of the kallikrein-kinin system in steroid-induced hypertension, we considered the possibility that the angiotensin-converting enzyme inhibitor captopril would lower the arterial blood pressure in deoxycorticosterone acetate (DOCA)\u2013salt hypertensive rats through kininase II inhibition. In conscious DOCA-salt hypertensive rats with intact kidneys (n=6) or uninephrectomized rats (n=5), the short-term administration of captopril (8 mg\/kg IV) decreased mean blood pressure from 141\u00b13 to 118\u00b13 mm Hg (<jats:italic>P<\/jats:italic>&lt;.05) and from 176\u00b112 to 158\u00b115 mm Hg (<jats:italic>P<\/jats:italic>&lt;.05), respectively. The maximal effect of captopril was manifested between 40 and 50 minutes after its administration, and blood pressure remained depressed for at least 2 hours. The bradykinin B<jats:sub>2<\/jats:sub>receptor antagonist Hoe 140 (500 \u03bcg\/kg IV) abolished the antihypertensive effect of captopril in the DOCA-salt hypertensive rats, indicating kinin involvement. Losartan, an angiotensin type 1 receptor antagonist, had no effect on blood pressure in another group of DOCA-salt hypertensive rats (n=9) and did not significantly change the response to captopril. No effect of the angiotensin-converting enzyme inhibitor was seen in normotensive control rats (n=5), indicating the absence of a nonspecific hypotensive action of the drug. Plasma renin activity was lower in the DOCA-salt hypertensive rats (0.7\u00b10.2 ng angiotensin I\/mL per hour, n=4) than in normotensive control rats (8.8\u00b11.7, n=4). The involvement of kinins in the antihypertensive effect of captopril in DOCA-salt hypertension supports the contention that the kallikrein-kinin system contributes to blood pressure regulation in this hypertension model.<\/jats:p>","DOI":"10.1161\/01.hyp.27.1.85","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Kinin-Mediated Antihypertensive Effect of Captopril in Deoxycorticosterone Acetate\u2013Salt Hypertension"],"prefix":"10.1161","volume":"27","author":[{"given":"Ke","family":"Chen","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology, University of Minnesota, Minneapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewei","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Minnesota, Minneapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl W.","family":"Dunham","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Minnesota, Minneapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben G.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Minnesota, Minneapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"F247","volume":"238","year":"1980","unstructured":"Carretero OA, Scicli AG. 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