{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:46:40Z","timestamp":1780584400167,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            11\u03b2-Hydroxysteroid dehydrogenase (11\u03b2-HSD) modulates the access of corticosteroids to their receptors and is important in blood pressure control. The excretion of renal 11\u03b2-HSD (ie, NAD\n            <jats:sup>+<\/jats:sup>\n            -dependent isoform) is thought to protect renal mineralocorticoid receptors from cortisol. To examine whether endogenous renal 11\u03b2-HSD inhibitory factor(s) may be involved in the pathophysiology of hypertension, we studied the urinary excretion of such inhibitors in 30 patients with low-renin essential hypertension and 20 normotensive control subjects. The effect of sodium restriction on the urinary excretion of the inhibitors was also evaluated in six normotensive control subjects. Urine was extracted with Sep-Pak cartridges and high-performance liquid chromatography. Endogenous renal 11\u03b2-HSD inhibitors were measured by the inhibition of 11\u03b2-HSD bioactivity in microsomes from the human kidney. The urinary excretion of the inhibitors was significantly increased in patients with low-renin essential hypertension (1280\u00b188 nmol\/d, mean\u00b1SEM) compared with normotensive control subjects (704\u00b156 nmol\/d) (\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). Ratios of urinary tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone did not differ significantly. Sodium restriction reduced the urinary excretion of the endogenous renal 11\u03b2-HSD inhibitors but did not affect the ratio of urinary tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone. Endogenous renal 11\u03b2-HSD inhibitory factors may contribute to the pathogenesis of low-renin essential hypertension by modulating the activity of 11\u03b2-HSD. Sodium intake may directly or indirectly regulate the inhibitory factors.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.27.2.197","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"197-201","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Endogenous Renal 11\u03b2-Hydroxysteroid Dehydrogenase Inhibitory Factors in Patients With Low-Renin Essential Hypertension"],"prefix":"10.1161","volume":"27","author":[{"given":"Yoshiyu","family":"Takeda","sequence":"first","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Miyamori","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Iki","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Inaba","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Furukawa","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Hatakeyama","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoyu","family":"Takeda","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(84)80001-X"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-5-757"},{"key":"e_1_3_1_3_2","first-page":"821","volume":"2","year":"1987","unstructured":"Stewart PM, Valentino R, Wallace AM, Burt D, Shackleton CHL, Edwards CRW. 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