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We describe a 44-year-old woman with normal supine blood pressure and severe orthostatic hypertension who did not demonstrate an initial decrease in cardiac output and had normal plasma and urinary catecholamines and renin release. Pharmacological tests of autonomic nervous system function showed an increased pressor sensitivity to norepinephrine (11 to 14 times normal), normal sensitivity to isoproterenol, diminished baroreceptor reflex sensitivity, and exquisite sensitivity to \u03b1-adrenergic blockers. This unusual case of orthostatic hypertension appears to be secondary to vascular adrenergic hypersensitivity.<\/jats:p>","DOI":"10.1161\/01.hyp.28.1.42","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"42-46","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Orthostatic Hypertension Due to Vascular Adrenergic Hypersensitivity"],"prefix":"10.1161","volume":"28","author":[{"given":"Neal L.","family":"Benowitz","sequence":"first","affiliation":[{"name":"the Clinical Pharmacology (N.L.B., S.Z., S.C.), Endocrinology (M.S.), and Cardiology (J.W., M.C.) 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