{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:09:30Z","timestamp":1764655770026,"version":"3.40.3"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>We studied the effects of the endogenous cannabinoid ligand anandamide on blood pressure, single unit activity of barosensitive neurons in the rostral ventrolateral medulla, and postganglionic splanchnic sympathetic nerve discharge in urethane-anesthetized rats. In rats with an intact baroreflex, an intravenous bolus of 4 mg\/kg anandamide caused a triphasic blood pressure response: transient hypotension, followed by a brief pressor and more prolonged depressor phase. Anandamide evoked a \u201cprimary\u201d increase in neuronal firing coincident with its pressor effect and a \u201csecondary,\u201d baroreflex-mediated rise coincident with its depressor effect at both sites. Pretreatment of rats with phentolamine or trimethaphan did not inhibit either the pressor response or the primary increase in splanchnic nerve discharge elicited by anandamide. In barodenervated rats, electrical stimulation of the rostral ventrolateral medulla increased blood pressure and splanchnic nerve discharge. Anandamide treatment blunted the rise in blood pressure without affecting the increase in splanchnic nerve discharge. Anandamide did not affect the rise in blood pressure in response to an intravenous bolus dose of phenylephrine. The results indicate that (1) the brief pressor response to anandamide is not sympathetically mediated, and (2) the prolonged hypotensive response to anandamide is not initiated in the central nervous system, in ganglia, or at postsynaptic adrenergic receptors but is due to a presynaptic action that inhibits norepinephrine release from sympathetic nerve terminals in the heart and vasculature.<\/jats:p>","DOI":"10.1161\/01.hyp.28.4.682","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"682-686","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Mechanism of the Hypotensive Action of Anandamide in Anesthetized Rats"],"prefix":"10.1161","volume":"28","author":[{"given":"Karoly","family":"Varga","sequence":"first","affiliation":[{"name":"the Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond (K.V., K.D.L., G.K.), and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville (D.H., P.G.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy D.","family":"Lake","sequence":"additional","affiliation":[{"name":"the Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond (K.V., K.D.L., G.K.), and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville (D.H., P.G.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghai","family":"Huangfu","sequence":"additional","affiliation":[{"name":"the Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond (K.V., K.D.L., G.K.), and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville (D.H., P.G.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice G.","family":"Guyenet","sequence":"additional","affiliation":[{"name":"the Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond (K.V., K.D.L., G.K.), and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville (D.H., P.G.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Kunos","sequence":"additional","affiliation":[{"name":"the Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond (K.V., K.D.L., G.K.), and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville (D.H., P.G.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"1255","volume":"226","year":"1970","unstructured":"Dewey WL, Harris LS, Howes JF, Kennedy JS, Granchelli FE, Pars HG, Razdan RK. 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