{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:27Z","timestamp":1792003167329,"version":"4.4.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>The participation of substance P in the pathogenesis of five models of experimental hypertension, ie, DOCA-salt, subtotal nephrectomy, one-kidney-one clip renovascular, two-kidney-one clip renovascular, and spontaneous hypertension, was evaluated via an acute infusion of a newly synthesized potent, specific nonpeptide antagonist of substance P at the NK-1 receptor, the agent CP 96,345. In conscious unrestrained rats, CP 96,345 induced significant and sustained increases in mean arterial pressure of DOCA-salt, subtotal nephrectomy, and one-kidney-one clip renovascular hypertensive rats but only small and nonsignificant changes in blood pressure of two-kidney-one clip renovascular and spontaneously hypertensive rats. CP 96,345 had no effect on the blood pressure of sham-treated controls and Wistar-Kyoto rats. This NK-1 receptor antagonist did not significantly affect the heart rate of any experimental model studied. The data suggest that endogenous substance P may act as a partial counterregulatory mechanism against vasoconstriction in models of salt-dependent hypertension.<\/jats:p>","DOI":"10.1161\/01.hyp.29.1.506","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"506-509","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Role of Substance P in Blood Pressure Regulation in Salt-Dependent Experimental Hypertension"],"prefix":"10.1161","volume":"29","author":[{"suffix":"Jr","given":"Osvaldo","family":"Kohlmann","sequence":"first","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Luis","family":"Cesaretti","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Ginoza","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostinho","family":"Tavares","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Zanella","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Beltrame","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo Luiz","family":"Ramos","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Leeman","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gavras","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haralambos","family":"Gavras","sequence":"additional","affiliation":[{"name":"From the Nephrology Division, Federal University of Sa\u0303o Paulo, Brazil, and Department of Medicine, Boston (Mass) University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.2.229"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90633-2"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360105"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11579.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1975.tb05800.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1975.tb05816.x"},{"key":"e_1_3_1_7_2","unstructured":"Burcher E Atterhog JH Pernow B Rossel S. 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