{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T22:10:25Z","timestamp":1743372625190,"version":"3.40.3"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>The vasopressin receptor subtype that causes nitric oxide (NO) release remains controversial. To elucidate this receptor-ligand interaction, we examined the effects of vasopressin receptor antagonists on vasopressin-induced release of NO from isolated perfused rat kidneys by using a sensitive chemiluminescence assay. Vasopressin increased renal perfusion pressure and NO signals in the perfusate in a dose-dependent manner.<jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>-Monomethyl-<jats:sc>l<\/jats:sc>-arginine abolished this increase in NO release; however, a similar increase in renal perfusion pressure induced by prostaglandin F<jats:sub>2\u03b1<\/jats:sub>was not associated with the increase in NO release. OPC-21268, a V<jats:sub>1<\/jats:sub>receptor antagonist, significantly reduced the vasopressin-evoked renal vasoconstriction and NO release, whereas OPC-31260, a V<jats:sub>2<\/jats:sub>receptor antagonist, had no effects. Moreover, desmopressin, a selective V<jats:sub>2<\/jats:sub>receptor agonist, did not increase the NO signal. NO release by vasopressin was markedly attenuated in deoxycorticosterone acetate (DOCA)\u2013salt hypertensive rat kidneys compared with control kidneys (10<jats:sup>\u221210<\/jats:sup>mol\/L vasopressin: +0.8\u00b10.3 versus +6.9\u00b11.4 fmol\/min per gram kidney, DOCA versus control;<jats:italic>P<\/jats:italic>&lt;.001). Histochemical analysis for renal NO synthase revealed a substantial attenuation of the staining of endothelial NO synthase in DOCA-salt rats. These results directly demonstrate that vasopressin stimulates NO release via the endothelial V<jats:sub>1<\/jats:sub>receptor in the rat kidney.<\/jats:p>","DOI":"10.1161\/01.hyp.29.1.58","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Receptor Subtype for Vasopressin-Induced Release of Nitric Oxide From Rat Kidney"],"prefix":"10.1161","volume":"29","author":[{"given":"Yasunobu","family":"Hirata","sequence":"first","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Kakoki","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tojo","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Nagata","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Goto","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nagano","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Hirobe","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Omata","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine (Y.H., H.H., M.K., A.T., E.S., D.N., K.K, A.G., M.O.) and Faculty of Pharmaceutical Sciences (K.K., T.N., M.H.), University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89121-9"},{"key":"e_1_3_2_2_2","unstructured":"Thibonnier M. 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