{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:28:06Z","timestamp":1771644486874,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>\n            We measured Na\n            <jats:sup>+<\/jats:sup>\n            -H\n            <jats:sup>+<\/jats:sup>\n            exchange as the amiloride-inhibited fraction of H\n            <jats:sup>+<\/jats:sup>\n            efflux from red blood cells into a sodium-containing medium (pH\n            <jats:sub>o<\/jats:sub>\n            7.95 to 8.05) at pH\n            <jats:sub>i<\/jats:sub>\n            values of 6.05 to 6.15, 6.35 to 6.45, 6.95 to 7.05, and 7.35 to 7.45 in 12 drug-free patients with primary aldosteronism before and after excision of histologically proven aldosterone-producing adrenal adenoma, 12 drug-free essential hypertensive patients, and 12 healthy control subjects. Red blood cell Na\n            <jats:sup>+<\/jats:sup>\n            -H\n            <jats:sup>+<\/jats:sup>\n            exchange was increased in patients with primary aldosteronism similarly to the mean exchanger velocity in essential hypertensive patients compared with values in healthy subjects (334\u00b125 and 310\u00b129 versus 139\u00b121 \u03bcmol H\n            <jats:sup>+<\/jats:sup>\n            \/L cells per minute, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001 and .01). The kinetic parameters of Na\n            <jats:sup>+<\/jats:sup>\n            -H\n            <jats:sup>+<\/jats:sup>\n            exchange returned to normal on day 2 after removal of the aldosterone-producing mass.\n            <jats:italic>K<\/jats:italic>\n            <jats:sub>m<\/jats:sub>\n            for [Na\n            <jats:sup>+<\/jats:sup>\n            ]\n            <jats:sub>o<\/jats:sub>\n            was not affected by aldosterone, whereas\n            <jats:italic>K<\/jats:italic>\n            <jats:sub>m<\/jats:sub>\n            for [H\n            <jats:sup>+<\/jats:sup>\n            ]\n            <jats:sub>i<\/jats:sub>\n            was decreased in patients with primary aldosteronism. The kinetic characteristics did not differ in essential hypertensive patients and control subjects. Protein kinase C inhibition in vitro by calphostin C (60 nmol\/L) increased\n            <jats:italic>K<\/jats:italic>\n            <jats:sub>m<\/jats:sub>\n            for [H\n            <jats:sup>+<\/jats:sup>\n            ]\n            <jats:sub>i<\/jats:sub>\n            and caused up to a 65% suppression of Na\n            <jats:sup>+<\/jats:sup>\n            -H\n            <jats:sup>+<\/jats:sup>\n            exchange (pH\n            <jats:sub>i<\/jats:sub>\n            6.05 to 6.15), while diminishing\n            <jats:italic>K<\/jats:italic>\n            <jats:sub>m<\/jats:sub>\n            for [Na+]\n            <jats:sub>o<\/jats:sub>\n            in red blood cells of patients with primary aldosteronism. The calmodulin antagonist W-13 (60 mmol\/L) decreased exchanger velocity and increased\n            <jats:italic>K<\/jats:italic>\n            <jats:sub>m<\/jats:sub>\n            for both H\n            <jats:sup>+<\/jats:sup>\n            and Na\n            <jats:sup>+<\/jats:sup>\n            . We conclude that aldosterone stimulates red blood cell Na\n            <jats:sup>+<\/jats:sup>\n            -H\n            <jats:sup>+<\/jats:sup>\n            exchange by a nongenomic mechanism that augments the exchanger affinity to Na\n            <jats:sup>+<\/jats:sup>\n            and H\n            <jats:sup>+<\/jats:sup>\n            . In primary aldosteronism, protein kinase C and calmodulin seem to have synergistic stimulatory effects on red blood cell Na\n            <jats:sup>+<\/jats:sup>\n            -H\n            <jats:sup>+<\/jats:sup>\n            exchange, and both increase the affinity of the exchanger to H\n            <jats:sup>+<\/jats:sup>\n            , while their effect on Na\n            <jats:sup>+<\/jats:sup>\n            binding is opposite.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.29.2.587","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"587-591","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Increased Na\n            <sup>+<\/sup>\n            -H\n            <sup>+<\/sup>\n            Exchange in Red Blood Cells of Patients With Primary Aldosteronism"],"prefix":"10.1161","volume":"29","author":[{"given":"Wladimir","family":"Koren","sequence":"first","affiliation":[{"name":"the Central Research Laboratory, Ministry of Public Health, Moscow, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya Y.","family":"Postnov","sequence":"additional","affiliation":[{"name":"the Central Research Laboratory, Ministry of Public Health, Moscow, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuvenaly V.","family":"Postnov","sequence":"additional","affiliation":[{"name":"the Central Research Laboratory, Ministry of Public Health, Moscow, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"378","volume":"87","year":"1992","unstructured":"Duesing R, Goebel BO, Hoffman G, Wetter H, Siffert W. 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