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After the diet regimen, baseline levels of mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and the overall and central properties of the ABR were compared among the four groups of rats under halothane anesthesia. In WKY, a high salt diet did not affect baseline arterial pressure and RSNA but potentiated the ABR, as evidenced by an increase in the maximal slope of MAP-RSNA and MAP\u2013heart rate relationships. In SHR, by contrast, salt loading accelerated hypertension and sympathetic overactivity and impaired the ABR. Salt-induced modulation of the ABR was associated with that of the central property, since reflex inhibition of RSNA by stimulation of the aortic depressor nerve was augmented in WKY and attenuated in SHR. These results suggest that differential modulation of the central mechanism subserving the baroreflex control of sympathetic activity at least partly accounts for the difference in salt sensitivity between WKY and SHR.<\/jats:p>","DOI":"10.1161\/01.hyp.29.3.808","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"808-814","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Differential Central Modulation of the Baroreflex by Salt Loading in Normotensive and Spontaneously Hypertensive Rats"],"prefix":"10.1161","volume":"29","author":[{"given":"Ayumu","family":"Ono","sequence":"first","affiliation":[{"name":"the Fourth Department of Internal Medicine (A.O., T.F.) and Department of Physiology (T.K., M.K.), The University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kuwaki","sequence":"additional","affiliation":[{"name":"the Fourth Department of Internal Medicine (A.O., T.F.) and Department of Physiology (T.K., M.K.), The University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Kumada","sequence":"additional","affiliation":[{"name":"the Fourth Department of Internal Medicine (A.O., T.F.) and Department of Physiology (T.K., M.K.), The University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Fujita","sequence":"additional","affiliation":[{"name":"the Fourth Department of Internal Medicine (A.O., T.F.) and Department of Physiology (T.K., M.K.), The University of Tokyo (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/3.8.179"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.1.227S"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.7.3.357"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.11.4.326"},{"key":"e_1_3_2_5_2","first-page":"926","volume":"251","year":"1986","unstructured":"Fujita T, Sato Y, Ando K. 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