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Clips with a lumen of 0.11 mm induced a high percentage of renal infarction, and clips with a 0.13-mm opening did not produce hypertension. Four weeks after clipping, two-kidney, one clip hypertensive mice exhibited blood pressure approximately 20 mm Hg higher than their sham-operated controls. After a similar period, this increase reached almost 35 mm Hg in the one-kidney, one clip model. Depending on the model, mice develop either renin-dependent or renin-independent hypertension. Both models are characterized by the development of cardiovascular hypertrophy.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.29.4.1025","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"1025-1030","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":139,"title":["Two-Kidney, One Clip and One-Kidney, One Clip Hypertension in Mice"],"prefix":"10.1161","volume":"29","author":[{"given":"Philippe","family":"Wiesel","sequence":"first","affiliation":[{"name":"From the Division of Hypertension, University of Lausanne (Switzerland) Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Mazzolai","sequence":"additional","affiliation":[{"name":"From the Division of Hypertension, University of Lausanne (Switzerland) Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rg","family":"Nussberger","sequence":"additional","affiliation":[{"name":"From the Division of Hypertension, University of Lausanne (Switzerland) Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pedrazzini","sequence":"additional","affiliation":[{"name":"From the Division of Hypertension, University of Lausanne (Switzerland) Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899209148338"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.9.8005386"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.73.1.8508532"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.40.030178.002113"},{"key":"e_1_3_2_5_2","unstructured":"Gunning ME Ingelfinger JR King AJ Brenner BM. 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