{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:53:54Z","timestamp":1762271634058},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            Calcitonin gene\u2013related peptide (CGRP) is a potent vasodilator neuropeptide. We previously demonstrated that neuronal CGRP expression is significantly increased in deoxycorticosterone (DOC)\u2013salt hypertensive rats. To determine the hemodynamic role of CGRP in this setting, we used CGRP\n            <jats:sub>8-37<\/jats:sub>\n            , a specific CGRP receptor antagonist. DOC-salt hypertension was induced in Sprague-Dawley rats. To control for DOC pellet implantation, left nephrectomy, and\/or saline drinking water, we also studied four normotensive groups. Four weeks after the initiation of each protocol, all rats had intravenous (for drug administration) and arterial (for continuous mean arterial pressure monitoring) catheters surgically placed and were studied in the conscious, unrestrained state. Baseline mean arterial pressure was higher in the DOC-salt than normotensive rats (175\u00b15 versus 119\u00b14 mm Hg,\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). Vehicle administration did not alter mean arterial pressure in any group, and CGRP\n            <jats:sub>8-37<\/jats:sub>\n            administration (bolus doses of 3.2\u00d710\n            <jats:sup>4<\/jats:sup>\n            or 6.4\u00d710\n            <jats:sup>4<\/jats:sup>\n            pmol\/L) did not change mean arterial pressure in the four normotensive groups. However, CGRP\n            <jats:sub>8-37<\/jats:sub>\n            administration to the DOC-salt rats rapidly and significantly increased mean arterial pressure at both the lower dose (9\u00b11 mm Hg,\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) and higher dose (14\u00b11 mm Hg,\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). In addition, the increase in mean arterial pressure between the two CGRP\n            <jats:sub>8-37<\/jats:sub>\n            doses was also significant (\n            <jats:italic>P<\/jats:italic>\n            &lt;.01), indicating a dose-dependent response. We conclude that the increase in neuronal CGRP expression in DOC-salt hypertension plays a compensatory vasodilator role to attenuate the elevated blood pressure. These results provide the first conclusive evidence that CGRP plays a direct role in DOC-salt hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.29.4.945","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"945-950","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Calcitonin Gene\u2013Related Peptide Is a Depressor of Deoxycorticosterone-Salt Hypertension in the Rat"],"prefix":"10.1161","volume":"29","author":[{"given":"Scott C.","family":"Supowit","sequence":"first","affiliation":[{"name":"From the Departments of Internal Medicine (Division of General Internal Medicine) and Human Biological Chemistry and Genetics, The University of Texas (Galveston) Medical Branch."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawei","family":"Zhao","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Division of General Internal Medicine) and Human Biological Chemistry and Genetics, The University of Texas (Galveston) Medical Branch."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M.","family":"Hallman","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Division of General Internal Medicine) and Human Biological Chemistry and Genetics, The University of Texas (Galveston) Medical Branch."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald J.","family":"DiPette","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Division of General Internal Medicine) and Human Biological Chemistry and Genetics, The University of Texas (Galveston) Medical Branch."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/304129a0"},{"key":"e_1_3_2_2_2","unstructured":"DiPette DJ Wimalawansa SJ. Cardiovascular actions of calcitropic hormones. In: Crass J Avioli LV eds. Calcium Regulating Hormones and Cardiovascular Function. Baltimore Md: CRC Press; 1994:239-252."},{"key":"e_1_3_2_3_2","unstructured":"McEwan JS Legon SJ Wimalawansa SJ Zaidi M Dollery CT MacIntyre I. Calcitonin gene-related peptide: a review of its biology and relevance to the cardiovascular system. In: Laragh JH Brenner BM Kaplan NM eds. Endocrine Mechanisms in Hypertension. New York NY: Raven Press Publishers; 1989:287-304."},{"key":"e_1_3_2_4_2","first-page":"3101","volume":"12","year":"1984","unstructured":"Gibson SJ, Polak MR, Bloom SR, Sabate IM, Mulderry PM, Evans RM, Rosenfeld MG. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species. J Neurosci. 1984;12:3101-3111.","journal-title":"J Neurosci"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902660304"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90413-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198902000-00001"},{"key":"e_1_3_2_8_2","first-page":"267","volume":"3","year":"1989","unstructured":"Edvinson L, Ekman R, Thulin T. Reduced levels of calcitonin gene-related peptide (CGRP) but not substance P during and after treatment of severe hypertension in man. J Hum Hypertens. 1989;3:267-272.","journal-title":"J Hum Hypertens"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199210120-00010"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/4.7.565"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.21.6.1010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90609-W"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.25.6.1333"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Resnick LM Preibisz JJ Laragh JH. Calcitonin gene-related peptide-like immunoreactivity in hypertension: relation to blood pressure sodium and calcium metabolism. In: Rettig R Ganten D Luft P eds. Salt and Hypertension. New York NY: Springer-Verlag; 1989:190-199.","DOI":"10.1007\/978-3-642-73917-0_17"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90313-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90774-H"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90504-J"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(90)90003-N"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12497.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02394.1988"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/9.19.4951"},{"key":"e_1_3_2_22_2","first-page":"5294","volume":"18","year":"1977","unstructured":"Chirgwin JM, Prezybyla AE, MacDonald AE, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched with ribonuclease. Biochemistry. 1977;18:5294-5299.","journal-title":"Biochemistry"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00461-X"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199006000-00003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.4.7522988"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90062-9"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90064-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500282"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90366-2"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00581.x"},{"key":"e_1_3_2_31_2","unstructured":"Yaksh TL Bailey Roddy DR Harty GJ. Peripheral release of substance P from primary afferents. In: Dubner R Gebhart GF Bond MR eds. Proceedings from the Vth World Congress on Pain. Amsterdam Netherlands: Elsevier; 1988:51-54."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13460.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91263-G"},{"key":"e_1_3_2_34_2","first-page":"564","volume":"26","year":"1995","unstructured":"Supowit SC, Hallman DM, Zhao H, DiPette DJ. Bradykinin regulates neuronal calcitonin gene-related peptide expression and release. Hypertension. 1995;26:564. Abstract.","journal-title":"Hypertension"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14290.x"},{"key":"e_1_3_2_36_2","unstructured":"Dockray GJ. Physiology of enteric neuropeptides. In: Johnson LR ed. Physiology of the Gastrointestinal Tract. New York NY: Raven Press Publishers; 1994:169-209."},{"key":"e_1_3_2_37_2","first-page":"771","volume":"344","year":"1990","unstructured":"Nelson MT, Huang JE, Brayden JE, Hescheler J, Standen NB. Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature. 1990;344:771-773.","journal-title":"Nature"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.26.6.1177"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","unstructured":"McCarron DA Yung NN Ugoretz BA Krutzik S. Disturbances of calcium metabolism in the spontaneously hypertensive rat. Hypertension. 1981;3(suppl I):I-162-I-167.","DOI":"10.1161\/01.HYP.3.3_Pt_2.I162"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.29.4.945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:22:48Z","timestamp":1715534568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.29.4.945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1161\/01.HYP.29.4.945"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.29.4.945","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]},"assertion":[{"value":"1996-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}