{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:51:45Z","timestamp":1781329905458,"version":"3.54.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            There is no literature report of a detailed  morphologic study of the aortic depressor nerve. The aim of this study  was to describe the general morphological aspects and to obtain  morphometric parameters for the aortic depressor nerve of  normotensive Wistar rats (n=12). Before the morphologic studies, nerves  were isolated and pressure-nerve activity curves were obtained. Basal  mean arterial pressure was 117\u00b15 mm Hg, the  systolic pressure threshold was 100\u00b17 mm Hg, and  mean arterial pressure at 50% of maximal activity was  115\u00b15 mm Hg and the baroreceptor gain 1.99\u00b10.09%\/mm Hg.  Semithin and thin sections of proximal and distal nerve segments were  then examined by light and electron microscopy, respectively. The main  nerve components were (1) unmyelinated and  myelinated axons; (2) Schwann cells; (3) capillary wall  endothelial cells and pericytes; (4) collagen fibers in  the epineurium and endoneurium and between perineurial cell layers; and  (5) fibroblasts and mast cells. The depressor nerves were found to  contain 204-996 axons per nerve, 80% of which, on average, were  unmyelinated, with a 4:1  unmyelinated\/myelinated axon ratio. The  unmyelinated axon histogram was unimodal, with a mean  diameter of 0.5\u00b10.02 \u03bcm. Myelinated fibers had  axons averaging 1.3\u00b10.06 \u03bcm in diameter and  representing 53% of the total fiber diameter. The ratio  between axonal and total fiber diameter of myelinated fiber  ranged from 0.4 to 0.8 and tended to increase with axon size. Proximal  and distal segments were morphologically similar. In conclusion, the  morphologic description of the depressor nerve provides important data  for further investigations of the structural basis of altered  baroreflex responses in conditions such as arterial  hypertension, aging, atherosclerosis, and  peripheral neuropathies.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.30.3.693","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"693-698","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["A Descriptive and Quantitative Light and Electron Microscopy Study of the Aortic Depressor Nerve in Normotensive Rats"],"prefix":"10.1161","volume":"30","author":[{"given":"Vale\u0301ria P. S.","family":"Fazan","sequence":"first","affiliation":[{"name":"From the Department of Biological Sciences, School of Medicine of  Tria\u0302ngulo Mineiro, Uberaba, Minas Gerais (V.P.S.F.), and the Departments  of Physiology (H.C.S.) and Neurology (A.A.B.) and University Hospital, School  of Medicine of Ribeira\u0303o Preto, USP, Ribeira\u0303o Preto, Sa\u0303o  Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio C.","family":"Salgado","sequence":"additional","affiliation":[{"name":"From the Department of Biological Sciences, School of Medicine of  Tria\u0302ngulo Mineiro, Uberaba, Minas Gerais (V.P.S.F.), and the Departments  of Physiology (H.C.S.) and Neurology (A.A.B.) and University Hospital, School  of Medicine of Ribeira\u0303o Preto, USP, Ribeira\u0303o Preto, Sa\u0303o  Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amilton A.","family":"Barreira","sequence":"additional","affiliation":[{"name":"From the Department of Biological Sciences, School of Medicine of  Tria\u0302ngulo Mineiro, Uberaba, Minas Gerais (V.P.S.F.), and the Departments  of Physiology (H.C.S.) and Neurology (A.A.B.) and University Hospital, School  of Medicine of Ribeira\u0303o Preto, USP, Ribeira\u0303o Preto, Sa\u0303o  Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1963.205.4.771"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005163"},{"key":"e_1_3_2_3_2","first-page":"303","volume":"114","year":"1958","unstructured":"McCubbin JW, Masson MC, Page H. 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