{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:05:15Z","timestamp":1715558715978},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            Fifteen patients with Bartter\u2019s syndrome (hyponatremic hypochloremic hypokalemic metabolic alkalosis) were compared with 15 healthy volunteers. Red blood cell Na\n            <jats:sup>+<\/jats:sup>\n            \/H\n            <jats:sup>+<\/jats:sup>\n            and Cl\n            <jats:sup>\u2212<\/jats:sup>\n            \/HCO\n            <jats:sub>3<\/jats:sub>\n            <jats:sup>\u2212<\/jats:sup>\n            exchanges were enhanced in all patients with Bartter\u2019s syndrome. In calciuric normomagnesemic patients, sensitive to nonsteroidal anti-inflammatory drugs (classic Bartter\u2019s syndrome), red blood cell Na\n            <jats:sup>+<\/jats:sup>\n            ,K\n            <jats:sup>+<\/jats:sup>\n            ,2Cl\n            <jats:sup>\u2212<\/jats:sup>\n            cotransport was markedly reduced, calcium-dependent K\n            <jats:sup>+<\/jats:sup>\n            permeability was moderately increased, and up to 60% of sodium permeability was represented by cAMP-activated fraction (presumably human analog of \u03b2-isoform of Na\n            <jats:sup>+<\/jats:sup>\n            \/H\n            <jats:sup>+<\/jats:sup>\n            exchange). In noncalciuric hypomagnesemic patients insensitive to indomethacin (Gitelman\u2019s syndrome), Na\n            <jats:sup>+<\/jats:sup>\n            ,K\n            <jats:sup>+<\/jats:sup>\n            ,2Cl\n            <jats:sup>\u2212<\/jats:sup>\n            cotransport was enhanced, Na\n            <jats:sup>+<\/jats:sup>\n            permeability was increased due to calmodulin-dependent fraction, and calcium-dependent K\n            <jats:sup>+<\/jats:sup>\n            permeability was markedly enhanced. A new subtype of Bartter-like syndrome (\u201cvariant Bartter\u2019s syndrome\u201d) has been described in which calciuria, hypomagnesemia, and insensitivity to nonsteroidal anti-inflammatory drugs were associated with decreased Na\n            <jats:sup>+<\/jats:sup>\n            ,K\n            <jats:sup>+<\/jats:sup>\n            ,2Cl\n            <jats:sup>\u2212<\/jats:sup>\n            cotransport, enhanced calmodulin-activated fraction of Na\n            <jats:sup>+<\/jats:sup>\n            influx, and reduced calcium-dependent K\n            <jats:sup>+<\/jats:sup>\n            permeability.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.30.6.1338","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"1338-1341","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Membrane Ion Transport in Bartter\u2019s Syndrome"],"prefix":"10.1161","volume":"30","author":[{"given":"Wladimir","family":"Koren","sequence":"first","affiliation":[{"name":"From the Chorley Institute for Hypertension, Sheba Medical Center Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University (Israel) (W.K., E.P., T.R.), and the Department of Pathology, The Cardiology Center, Moscow, Russia (Y.V.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna","family":"Peleg","sequence":"additional","affiliation":[{"name":"From the Chorley Institute for Hypertension, Sheba Medical Center Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University (Israel) (W.K., E.P., T.R.), and the Department of Pathology, The Cardiology Center, Moscow, Russia (Y.V.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talma","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"From the Chorley Institute for Hypertension, Sheba Medical Center Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University (Israel) (W.K., E.P., T.R.), and the Department of Pathology, The Cardiology Center, Moscow, Russia (Y.V.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuvenaly V.","family":"Postnov","sequence":"additional","affiliation":[{"name":"From the Chorley Institute for Hypertension, Sheba Medical Center Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University (Israel) (W.K., E.P., T.R.), and the Department of Pathology, The Cardiology Center, Moscow, Russia (Y.V.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(62)90214-0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.31.020180.002201"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90401-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1972.00320010045003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90029-2"},{"key":"e_1_3_2_6_2","first-page":"67","volume":"31","year":"1975","unstructured":"Chan JCM, Malekzade MH, Anand SK. 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Miner Electrolyte Metab. 1978;1:225-230.","journal-title":"Miner Electrolyte Metab"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000168435"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-152"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1985.249.5.C527"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.388"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74423-8"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)52921-5"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.30.6.1338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:24:43Z","timestamp":1715534683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.30.6.1338"}},"subtitle":["Evidence for a New Syndrome Subtype"],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.1161\/01.HYP.30.6.1338"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.30.6.1338","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]},"assertion":[{"value":"1997-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}