{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:29:02Z","timestamp":1778275742080,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>\n            Prostaglandins contribute to the regulation of renin synthesis and secretion. We tested the hypothesis that the inducible isoform of prostaglandin G\/H synthase, cyclooxygenase-2, contributes to the stimulation of renin synthesis in renovascular hypertension. The expression of cyclooxygenase-2 and renin was investigated in the kidneys of rats with two-kidney, one-clip renovascular hypertension or sham operation. Systolic blood pressure was increased 2 weeks after clipping (153\u00b17 versus 112\u00b14 mm Hg in controls, n=6 each,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) and continued to rise until 4 weeks. Cyclooxygenase-2 mRNA levels were increased in clipped kidneys but remained unchanged or slightly decreased in nonclipped kidneys. Cyclooxygenase-2 protein was expressed mainly in the macula densa and occasionally in distal tubular cells not associated with the macula densa. Two weeks after clipping, the percentage of juxtaglomerular apparatus staining positive for cyclooxygenase-2 was 27.8\u00b13.6 in clipped kidneys, 3.1\u00b10.4 in contralateral kidneys, and 8.0\u00b11.3 in controls; the percentages for immunoreactive renin staining in the afferent arteriole were 33.6\u00b12 in clipped kidneys, 1.9\u00b10.5 in contralateral kidneys, and 12.4\u00b14.0 in controls, respectively. Similar parallel changes in renin and cyclooxygenase-2 staining were observed 4 weeks after clipping. The percentage of cyclooxygenase-2-positive juxtaglomerular apparatus correlated positively with the percentage that was renin positive (r=0.78,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). Double immunostaining showed coexpression of cyclooxygenase-2 and renin protein in the same juxtaglomerular apparatus. Our data are consistent with a role for macula densa cyclooxygenase-2 in the regulation of renin in renovascular hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.31.1.201","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"201-205","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":84,"title":["Coordinate Expression of Cyclooxygenase-2 and Renin in the Rat Kidney in Renovascular Hypertension"],"prefix":"10.1161","volume":"31","author":[{"given":"Andrea","family":"Hartner","sequence":"first","affiliation":[{"name":"From the Nephrology Research Laboratory, Department of Medicine IV, University of Erlangen-Nu\u0308rnberg, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete","family":"Goppelt-Struebe","sequence":"additional","affiliation":[{"name":"From the Nephrology Research Laboratory, Department of Medicine IV, University of Erlangen-Nu\u0308rnberg, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl F.","family":"Hilgers","sequence":"additional","affiliation":[{"name":"From the Nephrology Research Laboratory, Department of Medicine IV, University of Erlangen-Nu\u0308rnberg, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(95)90039-X"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90125-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/378406a0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117620"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.29.1.297"},{"key":"e_1_3_2_6_2","first-page":"1","year":"1989","unstructured":"Taugner R, Hackenthal E. 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