{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:27Z","timestamp":1790816187228,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>\n            There are anecdotal reports of early cerebrovascular complications occurring in patients with glucocorticoid-remediable aldosteronism (GRA). The issue has never been systematically evaluated. In this study, we retrospectively reviewed the International Registry for GRA to see if there was an association between cerebrovascular complications and GRA. We searched the records of 376 patients from 27 genetically proven GRA pedigrees for premature death or cerebrovascular complications. Each case was subsequently verified through the referring physician, or autopsy reports. The number of complications occurring in patients with proven GRA were compared to GRA negative subjects from the same pedigrees. There were 18 cerebrovascular events in 15 patients with proven GRA (n = 167) and none in the GRA negative group (n = 194;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). There were an additional 15 events in 15 subjects that were suspected of having GRA based on clinical history. Seventy percent of events were hemorrhagic strokes; the overall case fatality rate was 61%. The mean (\u00b1 SD) age at the time of the initial event was 31.7\u00b111.3 years. In total, 48% of all GRA pedigrees and 18% of all GRA patients had cerebrovascular complications, which is similar to the frequency of aneurysm in adult polycystic kidney disease. GRA is associated with high morbidity and mortality from early onset of hemorrhagic stroke and ruptured intracranial aneurysms. Screening for intracranial aneurysm with magnetic resonance angiography is advised for patients with genetically proven GRA.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.31.1.445","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"445-450","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":164,"title":["Intracranial Aneurysm and Hemorrhagic Stroke in Glucocorticoid-remediable Aldosteronism"],"prefix":"10.1161","volume":"31","author":[{"given":"W. Reid","family":"Litchfield","sequence":"first","affiliation":[{"name":"From the Endocrine-Hypertension Division, Brigham and Women\u2019s Hospital and Harvard Medical School (W.R.L., R.J.W., B.F.A., R.G.D.), Boston MA 02115 and Howard Hughes Medical Institute, Departments of Medicine and Genetics, Boyer Center for Molecular Medicine (R.P.L.), Yale University School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce F.","family":"Anderson","sequence":"additional","affiliation":[{"name":"From the Endocrine-Hypertension Division, Brigham and Women\u2019s Hospital and Harvard Medical School (W.R.L., R.J.W., B.F.A., R.G.D.), Boston MA 02115 and Howard Hughes Medical Institute, Departments of Medicine and Genetics, Boyer Center for Molecular Medicine (R.P.L.), Yale University School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruediger J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"From the Endocrine-Hypertension Division, Brigham and Women\u2019s Hospital and Harvard Medical School (W.R.L., R.J.W., B.F.A., R.G.D.), Boston MA 02115 and Howard Hughes Medical Institute, Departments of Medicine and Genetics, Boyer Center for Molecular Medicine (R.P.L.), Yale University School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Lifton","sequence":"additional","affiliation":[{"name":"From the Endocrine-Hypertension Division, Brigham and Women\u2019s Hospital and Harvard Medical School (W.R.L., R.J.W., B.F.A., R.G.D.), Boston MA 02115 and Howard Hughes Medical Institute, Departments of Medicine and Genetics, Boyer Center for Molecular Medicine (R.P.L.), Yale University School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Dluhy","sequence":"additional","affiliation":[{"name":"From the Endocrine-Hypertension Division, Brigham and Women\u2019s Hospital and Harvard Medical School (W.R.L., R.J.W., B.F.A., R.G.D.), Boston MA 02115 and Howard Hughes Medical Institute, Departments of Medicine and Genetics, Boyer Center for Molecular Medicine (R.P.L.), Yale University School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0992-66"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/355262a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00060793-199606000-00012"},{"key":"e_1_3_2_4_2","first-page":"3570","volume":"82","year":"1997","unstructured":"Litchfield WR, New MI, Coolidge C, Lifton RP, Dluhy RG. Evaluation of the dexamethasone suppression test for the diagnosis of glucocorticoid-remediable aldosteronism. J Clin Endocrinol Metab. 1997; 82 (11): 3570 \u20133573.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.847"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701023360106"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209243271303"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307293290508"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195305000-00004"},{"key":"e_1_3_2_10_2","first-page":"333","volume":"32","year":"1951","unstructured":"Brown RAP. Polycystic disease of the kidneys and intracranial aneurysms: the etiology and interrelationship of these conditions: review of recent literature and report of seven cases in which both conditions coexisted. Glasgow Med J. 1951; 32 : 333 \u2013348.","journal-title":"Glasgow Med J"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.58.4.0488"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198702000-00006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.66.4.0522"},{"key":"e_1_3_2_14_2","first-page":"I-110","volume":"7","year":"1985","unstructured":"Tobian L, Lange J, Ulm K, Wold L, Iwai J. Potassium reduced cerebral hemorrhage and death rate in hypertensive rats, even when blood pressure is not lowered. Hypertension. 1985; 7 : I-110 \u2013I-114.","journal-title":"Hypertension"},{"key":"e_1_3_2_15_2","first-page":"1507","volume":"82","year":"1997","unstructured":"Litchfield WR, Coolidge C, Silva P, Lifton RP, Fallo F, Williams GH, Dluhy RG. Impaired potassium-stimulated aldosterone production: a possible explanation for normokalemic glucocorticoid-remediable aldosteronism. J Clin Endocrinol Metab. 1997; 82 : 1507 \u20131510.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347840"},{"key":"e_1_3_2_17_2","unstructured":"Miyamori I Matsubara T Takeda R. Controversies in disorders of adrenal hormones. In: Takeda R Miyamori I eds. Idiopathic Hyperaldosteronism. Amsterdam: Elsevier Science; 1988: 111 ."},{"key":"e_1_3_2_18_2","first-page":"401","volume":"45","year":"1976","unstructured":"Beevers DG, Brown JJ, Ferriss JB, Fraser R, Lever AF, Robertson JIS, Tree M. Renal abnormalities and vascular complications in primary hyperaldosteronism. Evidence on tertiary hyperaldosteronism. Q J Med. 1976; 45 : 401 \u2013410.","journal-title":"Q J Med"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010183231602"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"12A","DOI":"10.1016\/0002-9149(93)90239-9","volume":"71","year":"1993","unstructured":"Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension. Am J Cardiol. 1993; 71 : 12A \u201316A.","journal-title":"Am J Cardiol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.67.6.1700933"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1993.1066"},{"key":"e_1_3_2_23_2","first-page":"285","volume":"14","year":"1965","unstructured":"Hall CE, Hall O. Hypertension and hypersalimentation. Lab Invest. 1965; 14 : 285 \u2013294.","journal-title":"Lab Invest"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3094199"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90056-F"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.9.1519278"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.5.8488517"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500170039006"},{"key":"e_1_3_2_29_2","first-page":"698","volume":"304","year":"1981","unstructured":"Wiebers DO, Whisnant JP, O\u2019Fallon WM. The natural history of unruptured intracranial aneurysms. N Engl J Med. 1981; 304 : 698 .","journal-title":"N Engl J Med"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401203300305"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420617"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1983.tb02880.x"},{"key":"e_1_3_2_33_2","first-page":"1071","volume":"82","year":"1997","unstructured":"Findling JW, Raff H, Hansson JH, Lifton RP. Liddle\u2019s syndrome: prospective genetic screening and suppressed aldosterone secretion in an extended kindred. J Clin Endocrinol Metab. 1997; 82 : 1071 \u20131074.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90250-X"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0995-76"},{"key":"e_1_3_2_36_2","first-page":"11495","volume":"11","year":"1995","unstructured":"Hansson JH, Schild L, Lu Y, Wilson TA, Gautschi I, Shimkets R, Nelson-Williams C, Rossier BC, Lifton RP. A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle\u2019s syndrome and identifies a proline-rich segment of the protein critical for regulation of channel activity. Proc Natl Acad Sci U S A. 1995; 11 : 11495 \u201311499.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V3121871"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.191.1.8134594"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209243271310"},{"key":"e_1_3_2_40_2","first-page":"506","volume":"38","year":"1996","unstructured":"Butler WE, Barker FGI, Crowell RM. Patients with polycystic kidney disease would benefit from routine magnetic resonance angiographic screening for intracerebral aneurysms: a decision analysis. Neurosurgery. 1996; 38 : 506 \u2013516.","journal-title":"Neurosurgery"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.31.1.445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:17:05Z","timestamp":1715534225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.31.1.445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1161\/01.HYP.31.1.445"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.31.1.445","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]},"assertion":[{"value":"1998-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}