{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:06:21Z","timestamp":1773281181030,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The Hypertension Optimal Treatment Study is a prospective trial conducted in 26 countries. The aims are to (1) evaluate the relationship between three levels of target office diastolic blood pressure (BP) (\u226480, \u226485, or \u226490 mm Hg) and cardiovascular morbidity and mortality in hypertensive patients and (2) examine the effects on cardiovascular morbidity and mortality of 75 mg aspirin daily versus placebo. A total of 19 193 patients between 50 and 80 years of age had been randomized by the end of April 1994. Treatment was initiated with felodipine 5 mg daily, and additional therapy was given in accordance with a set protocol. The present substudy of 926 patients performed in nine countries aimed to (1) compare home with office BP in a representative subsample of the HOT population after the titration of treatment was completed and (2) clarify whether the separation into the target groups could be expanded into the out-of-office setting. The differences between office and home measurements in diastolic BP of 0.2 mm Hg (SD, 9; 95% confidence interval, \u22120.36 to 0.81;\n            <jats:italic>P<\/jats:italic>\n            =.40) and systolic BP of 0.5 mm Hg (SD, 15; 95% confidence interval, \u22120.53 to 1.46;\n            <jats:italic>P<\/jats:italic>\n            =.21) were not significant. The group differences in home BP were 1.9 mm Hg (\u226480 versus \u226485) and 1.2 mm Hg (\u226485 versus \u226490) for diastolic BP (F=11.69; ANOVA,\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001) and 2.6 and 2.1 mm Hg for systolic BP (F=8.44,\n            <jats:italic>P<\/jats:italic>\n            =.0002). Thus, office and home BPs measured with the same semiautomatic device are comparable in treated hypertensive subjects in the HOT Study, and the separation into the target groups based on office readings prevails at home.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.31.4.1014","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"1014-1020","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Hypertension Optimal Treatment (HOT) Study"],"prefix":"10.1161","volume":"31","author":[{"given":"Sverre E.","family":"Kjeldsen","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hedner","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Jamerson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stevo","family":"Julius","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Haley","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Zabalgoitia","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir R.","family":"Butt","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Noor","family":"Rahman","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Hansson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Ullevaal University Hospital, Oslo, Norway (S.E.K.); the Department of Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg (T.H.); and Clinical Hypertension Research, University of Uppsala, Uppsala (L.H.), Sweden; the Division of Hypertension, University of Michigan Medical Center (Ann Arbor) (K.J., S.J.); Mayo Clinic, Jacksonville, Fla (W.E.H.); the Division of Cardiology, University of Texas Health Science Center at San Antonio (M.Z.); and the..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037059309077529"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037059209077502"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037059409102281"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037059509077613"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390180049008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037059309077523"},{"key":"e_1_3_2_7_2","unstructured":"Julius S. Home blood pressure monitoring: advantages and limitations. J Hypertens. 1991;9(suppl 3):S41\u2013S46."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199512000-00003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"O\u2019Brian E Petrie J Littler W de Swiet M Padfield PL O\u2019Malley K. The British Hypertension Society protocol for the evaluation of blood pressure measuring devices. J Hypertens. 1993;11(suppl 2):S43\u2013S62.","DOI":"10.1097\/00004872-199306000-00013"},{"key":"e_1_3_2_10_2","unstructured":"Lithell H Berglund L. Validation of an oscillometric blood pressure measuring device: a substudy of the HOT Study. Blood Pressure. In press."},{"key":"e_1_3_2_11_2","unstructured":"Altman DG Bland JM. Analysis of blood pressure data. In: Birkenh\u00e4ger WH Reid JL O\u2019Brien E O\u2019Malley K eds. Handbook of Hypertension Volume 14: Blood Pressure Measurement. New York NY: Elsevier; 1991:287\u2013314."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001469"},{"key":"e_1_3_2_13_2","first-page":"1261","volume":"1","year":"1980","unstructured":"Australian National Blood Pressure Management Committee. The Australian therapeutic trial in mild hypertension. Lancet. 1980;1:1261\u20131267.","journal-title":"Lancet"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6488.97"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.6.4.574"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","unstructured":"Kenny RA Brennan M O\u2019Malley K O\u2019Brien E. Blood pressure measurements in borderline hypertension. J Hypertens. 1987;5(suppl 5):S483\u2013S485.","DOI":"10.1097\/00004872-198712000-00040"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.11.6.545"},{"key":"e_1_3_2_18_2","unstructured":"Flapan AD Stewart SE Mcdougal F Padfield PL. Is self home-monitoring of blood pressure as good as 24-hour ambulatory monitoring? J Hypertens. 1987;5(suppl 5):S491\u2013S493."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90593-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1985.00360120103017"},{"key":"e_1_3_2_21_2","first-page":"133","volume":"7","year":"1989","unstructured":"Evans CE, Haynes RB, Goldsmith CH, Hewson SA. Home blood pressure-measuring devices: a comparative study of accuracy. J Hypertens. 1989;7:133\u2013142.","journal-title":"J Hypertens"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90180-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"Ruddy MC Bialy GB Malka ES Lacy CR Kostis JB. The relationship of plasma renin activity to clinic and ambulatory blood pressure in elderly people with isolated systolic hypertension. J Hypertens. 1988;6(suppl 4):S412\u2013S415.","DOI":"10.1097\/00004872-198812040-00129"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03720020027031"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02599528"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199606000-00016"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.31.4.1014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:46:13Z","timestamp":1715535973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.31.4.1014"}},"subtitle":["Home Blood Pressure in Treated Hypertensive Subjects"],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1161\/01.HYP.31.4.1014"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.31.4.1014","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]},"assertion":[{"value":"1997-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}