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The 1K1C rats were prepared and given tap water with or without supplementation of<jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>-nitro-<jats:sc>l<\/jats:sc>-arginine methyl ester (L-NAME). Systolic blood pressure (SBP) before and after renal artery clipping was measured with the tail-cuff method. Four weeks later, surgical unclipping was performed while blood pressure and renal function responses were determined. The results show that clipping the renal artery for 4 weeks increased SBP from 140\u00b15 to 183\u00b16 mm Hg (<jats:italic>P<\/jats:italic>&lt;0.05). Concurrent L-NAME treatment accelerated and aggravated the clipping-induced increases in SBP from 138\u00b16 to 219\u00b18 mm Hg (<jats:italic>P<\/jats:italic>&lt;0.05). Surgical unclipping reduced blood pressure to normotensive levels within 2 hours in all hypertensive rats with and without chronic or acute L-NAME treatment. However, the magnitude of reductions in blood pressure in the initial 1 hour after unclipping was significantly less in L-NAME\u2013treated rats than in nontreated rats (9\u00b12% versus 16\u00b11%,<jats:italic>P<\/jats:italic>&lt;0.05). Despite reducing blood pressure, unclipping significantly increased glomerular filtration rate, urine flow, and sodium and potassium excretions, but the extent of the increases in these renal functions was significantly attenuated in L-NAME\u2013treated rats. These data suggest that NO production partly contributes to the hypotensive and renal responses to unclipping but does not mediate the reversal of renovascular hypertension of this model.<\/jats:p>","DOI":"10.1161\/01.hyp.32.3.534","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"534-540","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Nitric Oxide Synthesis Inhibition Retards Surgical Reversal of One-Kidney Goldblatt Hypertension in Rats"],"prefix":"10.1161","volume":"32","author":[{"given":"Wann-Chu","family":"Huang","sequence":"first","affiliation":[{"name":"From the Graduate Institute of Medical Sciences, Tzu Chi College of Medicine, Hualien, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"From the Graduate Institute of Medical Sciences, Tzu Chi College of Medicine, Hualien, Taiwan, Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1969.217.2.458"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0470001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0660473"},{"key":"e_1_3_2_4_2","first-page":"263S","volume":"51","year":"1976","unstructured":"Gulati OP, Carretero OA, Morino T, Oza NB. 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