{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:31:06Z","timestamp":1773430266443,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The influence of chronic administration of the converting enzyme inhibitor captopril on blood pressure and sodium balance was evaluated in conscious Swiss Webster mice. Arterial pressure was measured with chronic indwelling catheters, and sodium balance was determined by infusing sodium intravenously in isotonic saline and collecting urine 24 h\/d. Experiments to validate sodium balance measurements in mice demonstrated recovery of 100\u00b13% of sodium intake under steady-state conditions (n=20 mice on 70 individual days, sodium intake range 160 to 1000 \u03bcmol\/d). It was further demonstrated that mean arterial pressure, heart rate, and body weight were unaltered from 115\u00b17 mm Hg, 646\u00b112 bpm, and 34\u00b10.6 g, respectively, as sodium intake was increased stepwise from 150 to 900 \u03bcmol NaCl per day. An additional validation group (n=7) demonstrated that daily and cumulative sodium balance can be accurately determined during and after the intravenous administration of an agent known to alter renal sodium handling (furosemide 50 mg \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 d\n            <jats:sup>\u22121<\/jats:sup>\n            ). Experiments were then performed to examine the influence of intravenous captopril infusion (40 mg \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 d\n            <jats:sup>\u22121<\/jats:sup>\n            , n=7) in mice in which the daily sodium intake was fixed at \u2248200 \u03bcmol\/d. This dose of captopril was determined to significantly decrease the pressor response to a 10-ng bolus of angiotensin I (Ang I) from 24\u00b15 in the control state to 6\u00b12 mm Hg (n=5). After 5 days of infusion of the converting enzyme inhibitor, mean arterial pressure significantly fell from 114\u00b13 to 58\u00b12 mm Hg, body weight significantly decreased from 36\u00b11 to 33\u00b11 g, and cumulative sodium balance significantly decreased to \u2212270\u00b155 \u03bcmol. These parameters returned toward control during 5 postcontrol days. Results of this study demonstrate that accurate sodium balance measurements can be obtained from individual conscious mice over a 5-fold range of sodium intake. The experiments also indicate that converting enzyme inhibition has a potent influence to lower blood pressure in normal mice; the hypotensive response appears to be due in part to increased urinary sodium excretion.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.32.5.923","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"923-928","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Chronic Sodium Balance and Blood Pressure Response to Captopril in Conscious Mice"],"prefix":"10.1161","volume":"32","author":[{"given":"David L.","family":"Mattson","sequence":"first","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristyn R.","family":"Krauski","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"S19","volume":"98","year":"1996","unstructured":"Chien KR. 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