{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:33:12Z","timestamp":1773459192075,"version":"3.50.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p><jats:italic>Abstract<\/jats:italic>\u2014Kinins have been shown to play an important role in the cardioprotective effect of ACE inhibitors (ACEi) during heart failure and ischemia-reperfusion. However, it is controversial as to whether kinins oppose the hypertensinogenic effect of deoxycorticosterone acetate plus salt (DOCA-salt) or aortic coarctation and whether they mediate both chronic antihypertensive and cardiac antihypertrophic effects of ACEi in hypertension. Using normal 129\/SvEvTac mice and mice lacking the bradykinin B<jats:sub>2<\/jats:sub>receptor gene (B<jats:sub>2<\/jats:sub>-KO), we investigated whether (1) the hypertensinogenic effect of DOCA-salt or aortic coarctation is enhanced in B<jats:sub>2<\/jats:sub>-KO mice and (2) the chronic antihypertensive and antihypertrophic effects of an ACEi (ramipril, 4 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 d<jats:sup>\u22121<\/jats:sup>) are mediated by B<jats:sub>2<\/jats:sub>receptors in aortic coarctation (6 weeks)\u2013 and DOCA-salt (4 weeks)\u2013induced hypertension. Before surgery, there was no difference between 129\/SvEvTac and B<jats:sub>2<\/jats:sub>-KO mice in terms of blood pressure and heart weight, suggesting that kinins are not essential to maintaining normal blood pressure. DOCA-salt (volume expansion) or aortic coarctation (renin-dependent) induced similar hypertension and left ventricular hypertrophy (LVH) in 129\/SvEvTac and B<jats:sub>2<\/jats:sub>-KO mice, suggesting that kinins do not play an essential role in the development of DOCA-salt\u2013 or aortic coarctation\u2013induced hypertension. We found that B<jats:sub>2<\/jats:sub>receptors mediate only the early (1 week) but not the late phase (4 weeks) of the chronic hypotensive effect of ACEi in DOCA-salt hypertension. On the other hand, chronic ACE inhibition prevented the development of hypertension and LVH in both 129\/SvEvTac and B<jats:sub>2<\/jats:sub>-KO mice given DOCA-salt or subjected to aortic coarctation, suggesting that kinins do not participate in the chronic antihypertensive and antihypertrophic effects of ACEi in these 2 models of hypertension. Thus, in mice, kinins acting via B<jats:sub>2<\/jats:sub>receptors do not participate in (1) maintenance of normal basal blood pressure, (2) establishment and maintenance of hypertension induced by DOCA-salt or aortic coarctation, and (3) chronic antihypertensive and cardiac antihypertrophic effects of ACEi in DOCA-salt and aortic coarctation hypertension.<\/jats:p>","DOI":"10.1161\/01.hyp.33.1.329","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of ACE Inhibitor on DOCA-Salt\u2013 and Aortic Coarctation\u2013Induced Hypertension in Mice"],"prefix":"10.1161","volume":"33","author":[{"given":"Nour-Eddine","family":"Rhaleb","sequence":"first","affiliation":[{"name":"From the Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Peng","sequence":"additional","affiliation":[{"name":"From the Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos E.","family":"Alfie","sequence":"additional","affiliation":[{"name":"From the Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward G.","family":"Shesely","sequence":"additional","affiliation":[{"name":"From the Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar A.","family":"Carretero","sequence":"additional","affiliation":[{"name":"From the Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.13.6.658"},{"key":"e_1_3_2_2_2","unstructured":"Carretero OA Scicli AG. 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