{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:34:02Z","timestamp":1778276042249,"version":"3.51.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014We hypothesized that the relatively high doses of angiotensin (Ang) II required to produce hypertension in rats were related to stimulation of renal medullary nitric oxide production, which in turn blunted reductions in medullary blood flow and the development of hypertension. Ang II was infused (5 days at 3 ng \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            IV) to uninephrectomized Sprague-Dawley rats in the presence and absence of a continuous medullary interstitial\n            <jats:italic>N<\/jats:italic>\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methyl ester (L-NAME) infusion. Renal cortical and medullary blood flows were determined with the use of implanted optical fibers and laser-Doppler flowmetry. Ang II in the absence of medullary nitric oxide synthase inhibition did not change cortical or medullary blood flow or mean arterial pressure. A threshold dose of L-NAME was determined (75 \u03bcg \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 h\n            <jats:sup>\u22121<\/jats:sup>\n            ) that did not produce significant short- or long-term changes in medullary blood flow and mean arterial pressure. In rats with blunted medullary nitric oxide synthase activity, Ang II infused intravenously resulted in a 30% reduction in medullary blood flow (from 1.3 to 0.9\u00b10.2V) and \u224820 mm Hg increase in mean arterial pressure with Ang II infusion over 5 days. During 70 minutes after the start of intravenous Ang II, there was an immediate reduction in medullary blood flow, with no changes in cortical blood flow or mean arterial pressure. We conclude that the relative insensitivity of rats to long-term elevations of circulating Ang II is due to the potent counterregulatory actions of the nitric oxide system, specifically within the renal medulla. The results provide novel insights of how the organism attempts to protect itself from the hypertensive effects of Ang II.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.33.1.440","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Local Renal Medullary L-NAME Infusion Enhances the Effect of Long-Term Angiotensin II Treatment"],"prefix":"10.1161","volume":"33","author":[{"suffix":"Jr","given":"Ma\u0301tya\u0301s","family":"Szentiva\u0301nyi","sequence":"first","affiliation":[{"name":"From the Clinical Research Deptartment, 2nd Institute of Physiology, Semmelweis University of Medicine, Budapest, Hungary (M.S.); Laboratorio de Cardiovascular, Department de Fisiologia, ICBS, UFRGS, Brasil (C.Y.M.); and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis (A.W.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Y.","family":"Maeda","sequence":"additional","affiliation":[{"name":"From the Clinical Research Deptartment, 2nd Institute of Physiology, Semmelweis University of Medicine, Budapest, Hungary (M.S.); Laboratorio de Cardiovascular, Department de Fisiologia, ICBS, UFRGS, Brasil (C.Y.M.); and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis (A.W.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Allen W.","family":"Cowley","sequence":"additional","affiliation":[{"name":"From the Clinical Research Deptartment, 2nd Institute of Physiology, Semmelweis University of Medicine, Budapest, Hungary (M.S.); Laboratorio de Cardiovascular, Department de Fisiologia, ICBS, UFRGS, Brasil (C.Y.M.); and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis (A.W.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.1.C1"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.39.6.1000771"},{"key":"e_1_3_2_3_2","first-page":"96","volume":"174","year":"1960","unstructured":"Laragh JH, Angers M, Kelly WG, Lieberman S. 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