{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:57:21Z","timestamp":1778637441697,"version":"3.51.4"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The purpose of this study was to determine the effect of dietary Mg deficiency (80 mg\/kg versus control diet: 960 mg\/kg) on blood pressure and mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously with an echo-tracking device. At 19 weeks, systolic, diastolic, and mean blood pressures were higher in Mg-deficient rats. Histological examination showed an increase in cross-sectional area, intima-media thickness, and media-to-lumen ratio in carotid artery of Mg-deficient rats. Mg deficiency did not modify the arterial distensibility\u2013blood pressure curve. At mean blood pressure, arterial distensibility was significantly less in 19-week-old rats than in 5-week-old rats of both control and Mg-deficient groups. A significant interaction between age and Mg-deficient diet on arterial distensibility (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.04) indicates an accelerated age-dependent decreased arterial distensibility with Mg deficiency. At 19 weeks, the artery was stiffer in hypertensive Mg-deficient rats, as illustrated by a shift to higher levels of the incremental elastic modulus\u2013stress curve. In conclusion, the increased blood pressure and the vascular morphological alterations observed in Mg-deficient rats may contribute to an accelerated alteration of the wall material, which in turn leads to a stiffening of the carotid artery.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.33.5.1105","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"1105-1110","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of Magnesium Deficiency on Blood Pressure and Mechanical Properties of Rat Carotid Artery"],"prefix":"10.1161","volume":"33","author":[{"given":"Pascal","family":"Laurant","sequence":"first","affiliation":[{"name":"From the Laboratoire Physiologie, Pharmacologie, et Nutrition Pre\u0301ventive Expe\u0301rimentale, UFR Me\u0301decine et Pharmacie, Universite\u0301 de Franche-Comte\u0301, Besanc\u0327on, France (P.L., A.B.), and the Division of Hypertension, CHUV, Lausanne, Switzerland (D.H., H.R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hayoz","sequence":"additional","affiliation":[{"name":"From the Laboratoire Physiologie, Pharmacologie, et Nutrition Pre\u0301ventive Expe\u0301rimentale, UFR Me\u0301decine et Pharmacie, Universite\u0301 de Franche-Comte\u0301, Besanc\u0327on, France (P.L., A.B.), and the Division of Hypertension, CHUV, Lausanne, Switzerland (D.H., H.R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans R.","family":"Brunner","sequence":"additional","affiliation":[{"name":"From the Laboratoire Physiologie, Pharmacologie, et Nutrition Pre\u0301ventive Expe\u0301rimentale, UFR Me\u0301decine et Pharmacie, Universite\u0301 de Franche-Comte\u0301, Besanc\u0327on, France (P.L., A.B.), and the Division of Hypertension, CHUV, Lausanne, Switzerland (D.H., H.R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Berthelot","sequence":"additional","affiliation":[{"name":"From the Laboratoire Physiologie, Pharmacologie, et Nutrition Pre\u0301ventive Expe\u0301rimentale, UFR Me\u0301decine et Pharmacie, Universite\u0301 de Franche-Comte\u0301, Besanc\u0327on, France (P.L., A.B.), and the Division of Hypertension, CHUV, Lausanne, Switzerland (D.H., H.R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"323","volume":"19","year":"1993","unstructured":"Altura BM, Zhang A, Altura BT. 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