{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:37:09Z","timestamp":1778276229112,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014To clarify the role of the sympathetic nervous system in the development of cyclosporine A (CsA)-induced rise in blood pressure (BP), the effects of CsA on 24-hour ambulatory BP (ABP) were studied in patients with familial amyloid polyneuropathy (FAP) who underwent a liver transplantation. On the basis of autonomic function tests, patients with absent or mild-to-moderate sympathetic damage (Group A, n=11, age 29 to 43 years, disease duration 2 to 6 years) and patients with severe sympathetic damage (Group B, n=9, age 27 to 38 years, disease duration 3 to 9 years) were identified. Both groups were followed for 1 year. The daily doses of CsA and the CsA whole blood trough levels between the groups did not differ. Pretransplantation values of daytime and nighttime ABP were, respectively, 117\u00b18\/76\u00b17 mm Hg and 108\u00b112\/68\u00b19 mm Hg in group A and 107\u00b16\/66\u00b14 mm Hg (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 group A versus group B) and 102\u00b16\/62\u00b14 mm Hg in group B. In response to CsA, BP increased in all patients, but more so in patients of group B than in patients of group A. One year after transplantation, daytime and nighttime ABP had increased by 6\u00b19\/3\u00b111% and 12\u00b110\/14\u00b114% in group A and by 12\u00b16\/13\u00b110% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) and 21\u00b111\/27\u00b121% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01) in group B. In both groups, the increase in nighttime ABP was greater than the increase in daytime ABP, which resulted in an attenuation or, even, a reversal of the diurnal BP rhythm. Because the rise in BP was greater in patients with more advanced sympathetic dysfunction, the sympathetic nervous system appears to counteract the CsA-induced rise in BP rather than causing it. This implies involvement of factors other than sympathetic activation in the pathogenesis of CsA-induced rise in BP in patients with familial amyloid polyneuropathy.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.34.1.102","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"102-106","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Sympathetic Nervous System in Cyclosporine-Induced Rise in Blood Pressure"],"prefix":"10.1161","volume":"34","author":[{"given":"Mario J.","family":"Carvalho","sequence":"first","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton H.","family":"van den Meiracker","sequence":"additional","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans","family":"Boomsma","sequence":"additional","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao","family":"Freitas","sequence":"additional","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie J.","family":"Man in \u2018t Veld","sequence":"additional","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidio","family":"Costa","sequence":"additional","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Falca\u0303o","family":"de Freitas","sequence":"additional","affiliation":[{"name":"From the Centro de Estudos de Func\u0327a\u0303o Autonomica, Hospital S. Joao, Oporto Medical School, Oporto (M.J.C., J.F., O.C., A.F.), Portugal, and the Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam (A.H.M., F.B., A.J.M.), The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112224"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/75.3.408"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(96)00110-5"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93127-M"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910123211505"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199612150-00011"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.22.2.257"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36181-1"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.71.3.3882266"},{"key":"e_1_3_1_10_2","first-page":"639","volume":"323","year":"1990","unstructured":"Scherrer U, Vissing SF, Morgan BJ, Rollins JA, Tindall RSA, Ring S, Hanson P, Mohanty PK, Victor RG. 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