{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:32:57Z","timestamp":1790429577203,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014We recently showed that rarefaction of skin capillaries in the dorsum of the fingers of patients with essential hypertension is due to the structural (anatomic) absence of capillaries rather than functional nonperfusion. It is not known whether this rarefaction is primary (ie, antedates the onset of hypertension) or secondary (ie, as a consequence of sustained and prolonged elevation of blood pressure [BP]). The aim of the present investigation was to study skin capillary density in a group of patients with mild borderline hypertension to assess whether rarefaction antedates the onset of sustained elevation of BP. The study group included 18 patients with mild borderline hypertension (mean supine BP, 136\/83 mm Hg), 32 normotensive controls (mean BP, 126\/77 mm Hg), and 45 patients with established essential hypertension (mean BP, 156\/98 mm Hg). The skin of the dorsum of the fingers was examined by intravital capillary videomicroscopy before and after venous congestion at 60 mm Hg for 2 minutes. Patients with borderline essential hypertension had the lowest resting capillary density when compared with normotensive controls and patients with established hypertension. Maximal capillary density with venous congestion in the borderline group remained the lowest. The study confirmed that patients with borderline essential hypertension have skin capillary densities that are equally low as or even lower than patients with established hypertension. Both groups had significantly lower capillary densities than normal controls. One explanation for the results is that capillary rarefaction may be due to an early structural abnormality in essential hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.34.4.655","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"655-658","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":189,"title":["Rarefaction of Skin Capillaries in Borderline Essential Hypertension Suggests an Early Structural Abnormality"],"prefix":"10.1161","volume":"34","author":[{"given":"Tarek F. T.","family":"Antonios","sequence":"first","affiliation":[{"name":"From the Blood Pressure Unit (T.F.T.A., N.D.M., G.A.M.), Dermatology Unit, Department of Medicine (P.S.M.), and the Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology (T.F.T.A., D.R.J.S.), St. George\u2019s Hospital Medical School, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R. J.","family":"Singer","sequence":"additional","affiliation":[{"name":"From the Blood Pressure Unit (T.F.T.A., N.D.M., G.A.M.), Dermatology Unit, Department of Medicine (P.S.M.), and the Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology (T.F.T.A., D.R.J.S.), St. George\u2019s Hospital Medical School, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala D.","family":"Markandu","sequence":"additional","affiliation":[{"name":"From the Blood Pressure Unit (T.F.T.A., N.D.M., G.A.M.), Dermatology Unit, Department of Medicine (P.S.M.), and the Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology (T.F.T.A., D.R.J.S.), St. George\u2019s Hospital Medical School, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Mortimer","sequence":"additional","affiliation":[{"name":"From the Blood Pressure Unit (T.F.T.A., N.D.M., G.A.M.), Dermatology Unit, Department of Medicine (P.S.M.), and the Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology (T.F.T.A., D.R.J.S.), St. George\u2019s Hospital Medical School, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"MacGregor","sequence":"additional","affiliation":[{"name":"From the Blood Pressure Unit (T.F.T.A., N.D.M., G.A.M.), Dermatology Unit, Department of Medicine (P.S.M.), and the Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology (T.F.T.A., D.R.J.S.), St. George\u2019s Hospital Medical School, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.4.998"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1933.02740440037011"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(49)90524-4"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199201000-00013"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199502000-00015"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.5.6.844"},{"key":"e_1_3_1_7_2","first-page":"151","volume":"17","year":"1999","unstructured":"Guidelines Subcommittee. 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