{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:45:55Z","timestamp":1773081955330,"version":"3.50.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The aim of the present study was to evaluate the sensitivity of the cardiopulmonary receptors in experimental diabetes induced by streptozotocin by the use of 2 different methods: (1) administration of increasing doses of serotonin to analyze peak changes of arterial pressure and heart rate for each given dose in conscious intact normal and diabetic rats; (2) expanding blood volume with the use of dextran (6%) to produce similar increases in left ventricular end-diastolic pressure to quantify the arterial pressure, heart rate, and renal sympathetic nerve activity in sinoaortic, denervated, anesthetized normal and diabetic rats. Blood samples were collected to measure blood glucose. Diabetic rats showed hyperglycemia (22\u00b10.7 versus 7\u00b10.2 mmol\/L), reduced body weight (226\u00b112 versus 260\u00b14 g) and heart rate (294\u00b114 versus 350\u00b110 bpm), and similar arterial pressure (104\u00b14 versus 113\u00b14 mm Hg) when compared with control rats. Serotonin induced significant bradycardia and hypotension, which were similar and proportional to the dose injected in both groups. Mean arterial pressure and heart rate decreases in response to volume overload were significantly lower in diabetic than in control rats. The reflex reduction of the renal sympathetic nerve activity as expressed by percentage changes in nerve activity in response to increasing left end-diastolic pressure was abolished in diabetic animals (1.9\u00b10.8% versus \u221214\u00b14%\/mm Hg in controls). These results showed an impairment of cardiopulmonary reflex control of circulation in diabetes during acute volume expansion. The normal responses to serotonin administration indicated that the cardiopulmonary reflex is still preserved in diabetic rats.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.34.4.813","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"813-817","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Cardiopulmonary Reflex Impairment in Experimental Diabetes in Rats"],"prefix":"10.1161","volume":"34","author":[{"given":"Vera Lucia Longo","family":"Oliveira","sequence":"first","affiliation":[{"name":"From the Experimental Division and Hypertension Unit, Heart Institute, University of Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson Dias","family":"Moreira","sequence":"additional","affiliation":[{"name":"From the Experimental Division and Hypertension Unit, Heart Institute, University of Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera de Moura Azevedo","family":"Farah","sequence":"additional","affiliation":[{"name":"From the Experimental Division and Hypertension Unit, Heart Institute, University of Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Consolim-Colombo","sequence":"additional","affiliation":[{"name":"From the Experimental Division and Hypertension Unit, Heart Institute, University of Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Moacyr","family":"Krieger","sequence":"additional","affiliation":[{"name":"From the Experimental Division and Hypertension Unit, Heart Institute, University of Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Claudia","family":"Irigoyen","sequence":"additional","affiliation":[{"name":"From the Experimental Division and Hypertension Unit, Heart Institute, University of Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112586"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(87)90005-1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.29.4.257"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331977602700908"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.11.10.846"},{"key":"e_1_3_1_6_2","first-page":"497","volume":"28","year":"1995","unstructured":"Maeda CY, Fernandes TG, Luthier F, Irigoyen MC. Streptozotocin diabetes changes arterial pressure and baroreflex sensitivity in rats. Braz J Med Biol Res. 1995;28:497\u2013501.","journal-title":"Braz J Med Biol Res"},{"key":"e_1_3_1_7_2","first-page":"H235","volume":"266","year":"1994","unstructured":"McDowell TS, Chapleau MW, Hajduczok G, Aboud FM. Baroreflex dysfunction in diabetes mellitus, I: selective impairment of parasympathetic control of heart rate. Am J Physiol. 1994;266:H235\u2013H243.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X1997000900006"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X1997000100018"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.26.6.1100"},{"key":"e_1_3_1_11_2","first-page":"R1017","volume":"23","year":"1989","unstructured":"DiBona G. Neural control in renal function in edema-forming states. Am J Physiol. 1989;23:R1017\u2013R1024.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.9.5.478"},{"key":"e_1_3_1_13_2","first-page":"F576","volume":"243","year":"1982","unstructured":"DiBona GF, Sawin LL. Effect of renal nerve stimulation on NaCl and H2O transport in Henle\u2019s loop of the rat. Am J Physiol. 1982;243:F576\u2013F580.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","unstructured":"Mark AL Mancia G. Cardiopulmonary baroreflex in humans. In: Sheperd JT Abboud FM eds. Handbook of Physiology: The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Washington DC: American Physiological Society; 1983:3:795\u2013813.","DOI":"10.1002\/cphy.cp020321"},{"key":"e_1_3_1_15_2","first-page":"H119","volume":"247","year":"1984","unstructured":"Ferrari A, Gordon FJ, Mark AL. Impairment of cardiopulmonary baroreflex in Dahl salt-sensitive rats fed low salt. Am J Physiol. 1984;247:H119\u2013H123.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","unstructured":"Irigoyen MC Moreira ED Ida F Pires M Cestari IA Krieger EM. Changes of renal sympathetic activity in acute and chronic conscious sinoaortic denervated rats. Hypertension. 1995;26(6 Part 2):1111\u20131116.","DOI":"10.1161\/01.HYP.26.6.1111"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.15.6.511"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1970.tb04802.x"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1973.tb05429.x"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.36.2.1078795"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.31.6.824"},{"key":"e_1_3_1_22_2","first-page":"H810","volume":"243","year":"1982","unstructured":"Thames MD, Miller BD, Abboud FM. Baroreflex regulation of renal nerve activity during volume expansion. Am J Physiol. 1982;243:H810\u2013H814.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.57.5.4053310"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.42.2.620444"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109315"},{"key":"e_1_3_1_26_2","first-page":"R1500","volume":"271","year":"1996","unstructured":"Veelken R, Hilgers KF, Ditting T, Fierlbeck W, Geiger H, Schmieder E. Subthreshold stimulation of a serotonin 5-HT3 reflex attenuates cardiovascular reflexes. Am J Physiol. 1996;271:R1500\u2013R1506.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.42.030180.002213"},{"key":"e_1_3_1_28_2","unstructured":"Coleridge JCG Coleridge HM. Chemoreflex regulation of the heart. In: Berne RM Sperelakis M eds. Handbook of Physiology: The Cardiovascular System. The Heart. Bethesda Md: American Physiological Society; 1979:1:653\u2013676."},{"key":"e_1_3_1_29_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1749-6632.1987.tb36219.x","volume":"499","year":"1987","unstructured":"Nathan C, Rolland Y. Pharmacological treatments that affect CNS activity: serotonin. Ann N Y Acad Sci. 1987;499:277\u2013296.","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00109-7"},{"key":"e_1_3_1_31_2","doi-asserted-by":"crossref","unstructured":"Abboud FM Thames MD. Interaction of cardiovascular reflexes in circulatory control. In: Sheperd JT Abboud FM eds. Handbook of Physiology: Peripheral Circulation and Organ Blood Flow. Bethesda Md: American Physiological Society; 1983:675\u2013753.","DOI":"10.1002\/cphy.cp020319"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X1997000400014"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.65.2.2752548"},{"key":"e_1_3_1_34_2","first-page":"R372","volume":"267","year":"1994","unstructured":"Patel KP, Zhang PL. Reduced renal sympathoinhibition in response to acute volume expansion in diabetic rat. Am J Physiol. 1994;267:R372\u2013R379.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000025867"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1977.132"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0710403"},{"key":"e_1_3_1_38_2","first-page":"187","volume":"9","year":"1986","unstructured":"Kikkawa R, Kitamura E, Fujiwarw Y, Haneda M, Shigeta Y. Biphasic alteration of renin-angiotensin-aldosterone system in streptozotocin-diabetic rats. Renal Physiol. 1986;9:187\u2013192.","journal-title":"Renal Physiol"},{"key":"e_1_3_1_39_2","first-page":"3","volume":"6","year":"1980","unstructured":"Piryova B, Natcheff NB, Kirkova, NL. Effect of renal denervation on glucose transport. Acta Physiol Pharmacol Bulg. 1980;6:3\u20138.","journal-title":"Acta Physiol Pharmacol Bulg"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.34.4.813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:24:08Z","timestamp":1715534648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.34.4.813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["10.1161\/01.HYP.34.4.813"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.34.4.813","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10]]},"assertion":[{"value":"1999-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}