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In the absence of drug treatment, after 1 week, aortic banding provoked an increase in carotid pressure associated with left ventricular hypertrophy (29%;<jats:italic>P<\/jats:italic>&lt;0.01). These changes were accompanied by increased myocardial expression of preproendothelin-1 (2.5 times;<jats:italic>P<\/jats:italic>&lt;0.05) and skeletal \u03b1-actin (3.6 times;<jats:italic>P<\/jats:italic>&lt;0.05), but the expression of cardiac \u03b1-actin was not modified. Oral administration of carvedilol at a dose of 30 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 d<jats:sup>\u22121<\/jats:sup>to rats with aortic banding normalized carotid pressure and left ventricular weight as well as preproendothelin-1 and skeletal \u03b1-actin gene expression. Carvedilol at a lower dose (7.5 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 d<jats:sup>\u22121<\/jats:sup>) and lacidipine 1 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 d<jats:sup>\u22121<\/jats:sup>had only moderate and nonsignificant effects on carotid pressure but largely prevented left ventricular hypertrophy (<jats:italic>P<\/jats:italic>&lt;0.01) and preproendothelin-1 overexpression (<jats:italic>P<\/jats:italic>&lt;0.05). Labetalol (60 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 d<jats:sup>\u22121<\/jats:sup>) tended to exert similar effects but insignificantly. These results show that the antihypertrophic properties of carvedilol and lacidipine are partly independent of their antihypertensive effects and may be related to their ability to blunt myocardial preproendothelin-1 overexpression. Moreover, carvedilol at a dose of 7.5 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 d<jats:sup>\u22121<\/jats:sup>did not prevent myocardial overexpression of skeletal \u03b1-actin, which suggests that, in this model, reexpression of a fetal gene can be activated by pressure overload independently of cardiac hypertrophy.<\/jats:p>","DOI":"10.1161\/01.hyp.34.6.1197","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:53:46Z","timestamp":1339462426000},"page":"1197-1201","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Carvedilol and Lacidipine Prevent Cardiac Hypertrophy and Endothelin-1 Gene Overexpression After Aortic Banding"],"prefix":"10.1161","volume":"34","author":[{"given":"Pierre-Emmanuel","family":"Massart","sequence":"first","affiliation":[{"name":"From the Departments of Cardiovascular Physiology (P-E.M., G.R.H.) and Experimental Pharmacology (J.K., T.G., M.W.), Universite\u0301 Catholique de Louvain, Brussels; and the Division of Endocrinology and Internal Medicine (J.D.), University Hospital of Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Donckier","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular Physiology (P-E.M., G.R.H.) and Experimental Pharmacology (J.K., T.G., M.W.), Universite\u0301 Catholique de Louvain, Brussels; and the Division of Endocrinology and Internal Medicine (J.D.), University Hospital of Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kyselovic","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular Physiology (P-E.M., G.R.H.) and Experimental Pharmacology (J.K., T.G., M.W.), Universite\u0301 Catholique de Louvain, Brussels; and the Division of Endocrinology and Internal Medicine (J.D.), University Hospital of Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"The\u0301ophile","family":"Godfraind","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular Physiology (P-E.M., G.R.H.) and Experimental Pharmacology (J.K., T.G., M.W.), Universite\u0301 Catholique de Louvain, Brussels; and the Division of Endocrinology and Internal Medicine (J.D.), University Hospital of Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy R.","family":"Heyndrickx","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular Physiology (P-E.M., G.R.H.) and Experimental Pharmacology (J.K., T.G., M.W.), Universite\u0301 Catholique de Louvain, Brussels; and the Division of Endocrinology and Internal Medicine (J.D.), University Hospital of Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Wibo","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular Physiology (P-E.M., G.R.H.) and Experimental Pharmacology (J.K., T.G., M.W.), Universite\u0301 Catholique de Louvain, Brussels; and the Division of Endocrinology and Internal Medicine (J.D.), University Hospital of Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30538-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.1.209"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116579"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.6.3221"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.5.8181145"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb01932.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00224-D"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.70.313"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00201-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.4.954"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Herizi A Jover B Bouriquet N Mimran A. 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