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Three to 4 weeks later, arterial and venous catheters were implanted for measurements of arterial and central venous pressures, respectively, and a silicone balloon catheter was permanently fixed in the right atrium to produce brief circulatory arrest. Venous smooth muscle activity was estimated on the basis of repeated measurements of mean circulatory filling pressure in conscious rats resting in their home cages. DOCA-salt\u2013treated rats were hypertensive and had elevated mean circulatory filling pressure compared with normotensive sham-operated rats. Blockade of the endothelin subtype A receptor with 1 mg\/kg ABT-627 IV decreased arterial blood pressure and mean circulatory filling pressure significantly more in hypertensive rats than in normotensive rats. Ganglionic blockade with 30 mg\/kg hexamethonium IV also decreased arterial blood pressure and mean circulatory filling pressure more in hypertensive than in normotensive rats. Pretreatment with ABT-627 did not affect subsequent hemodynamic responses to ganglionic blockade. We conclude that venous smooth muscle tone is increased in DOCA-salt hypertension through the independent actions of both endogenous endothelin-1 acting on subtype A receptors and sympathetically mediated venoconstrictor activity.<\/jats:p>","DOI":"10.1161\/01.hyp.35.1.464","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"464-469","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Mechanisms of Increased Venous Smooth Muscle Tone in Desoxycorticosterone Acetate-Salt Hypertension"],"prefix":"10.1161","volume":"35","author":[{"given":"Gregory D.","family":"Fink","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, Michigan State University (East Lansing)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, Michigan State University (East Lansing)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Galligan","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, Michigan State University (East Lansing)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.31.1.139"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.10.2.133"},{"key":"e_1_3_2_3_2","first-page":"H823","volume":"238","year":"1980","unstructured":"Yamamoto J, Trippodo NC, Ishise S, Frohlich ED. 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