{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:48:55Z","timestamp":1790948935244,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Primary aldosteronism is  characterized by autonomous production of  aldosterone and arterial hypertension, and it  occurs in 2 principal forms: aldosterone-producing adenoma  (APA) and idiopathic hyperaldosteronism (IHA). APA can be cured through  removal of the adenoma, whereas IHA leads to hypertension that must be  treated with medication. The origin of the autonomous  aldosterone production in IHA is poorly understood,  but genetic factors may contribute to its cause. To test the hypothesis  that variants of the aldosterone synthase gene may  contribute to susceptibility to IHA, we compared genotypes at 3  polymorphic sites in the\n            <jats:italic>CYP11B2<\/jats:italic>\n            gene in patients  with IHA (n=90) with those found in patients with APA (n=38), in  patients with essential hypertension (n=72), and in normotensive  individuals (n=102). We observed significant linkage disequilibrium  among the 3 polymorphisms with 2 frequent haplotypes in all groups  studied. One haplotype (C2R) was found to be increased in frequency in  the IHA group (47%) compared with the other groups, which had a  similar haplotype frequency (36%). The 3 polymorphisms studied  have been implicated in either essential hypertension or excess  aldosterone production in previous studies. Because  of the strong linkage disequilibrium, the observed results could be due  to the action of any 1 of the 3 alleles or to another allele in  linkage disequilibrium with them. Our results suggest that variations  in the\n            <jats:italic>CYP11B2<\/jats:italic>\n            gene may contribute to dysregulation of  aldosterone synthesis and lead to susceptibility to  IHA.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.3.694","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"694-698","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["<i>CYP11B2<\/i>\n            Gene Polymorphisms in Idiopathic Hyperaldosteronism"],"prefix":"10.1161","volume":"35","author":[{"given":"Paolo","family":"Mulatero","sequence":"first","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Schiavone","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fallo","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Rabbia","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Pilon","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Chiandussi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Pascoe","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Veglio","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Experimental Oncology (P.M., D.S.,  F.R., L.C., F.V.), Hypertension Unit, University of Torino, Torino, Italy;  Department of Medical and Surgical Sciences (F.F., C.P.), Division of  Endocrinology, University of Padova, Padova, Italy; and Fondation Jean Dausset  CEPH (L.P.), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812173392507"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/355262a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.4.1458"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-10-1513"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.32.2.198"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.3.4801"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/07435809509030459"},{"key":"e_1_3_2_8_2","first-page":"4347","volume":"81","year":"1996","unstructured":"Fardella CE, Rodriguez H, Montero J, Zhang G, Vignolo P, Rojas A, Villarroel L, Miller W. 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