{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:41:23Z","timestamp":1770079283226,"version":"3.49.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Blacks exhibit greater  vasoconstriction-mediated blood pressure (BP) increases in response to  stress than do whites. Endothelin-1 (ET-1), a potent  vasoconstrictive peptide, has been proposed as having a  role in racial differences in stress reactivity. We evaluated the  hemodynamic and plasma ET-1 levels of 41 (23 whites, 18  blacks, mean age 18.6 years) normotensive adolescent males at rest and  in response to a video game challenge and forehead cold stimulation.  Measurements were performed at catheter insertion and before and  immediately after the 2 stressors, which were separated by 20-minute  rest periods. Blacks exhibited higher absolute levels of  diastolic blood pressure, total peripheral  resistance index, or both in response to catheter insertion and to the  video game challenge and during recovery from video game challenge and  cold stimulation (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 for all). Blacks exhibited  higher absolute levels of ET-1 at every evaluation point  (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 for all) and greater increases in ET-1 in  response to both stressors (ps&lt;0.05). These findings suggest that  altered endothelial function may be involved in racial  differences in hemodynamic reactivity to stress and  possibly in the development of essential hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.3.722","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"722-725","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["Racial Differences in Endothelin-1 at Rest and in Response to Acute Stress in Adolescent Males"],"prefix":"10.1161","volume":"35","author":[{"given":"Frank A.","family":"Treiber","sequence":"first","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Jackson","sequence":"additional","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Davis","sequence":"additional","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Pollock","sequence":"additional","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaston","family":"Kapuku","sequence":"additional","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Mensah","sequence":"additional","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Pollock","sequence":"additional","affiliation":[{"name":"From the Georgia Prevention Institute (F.A.T., R.W.J., G.K., G.A.M.), the  Vascular Biology Center (J.S.P., D.M.P.), Departments of Pediatrics and  Psychiatry (F.A.T.), and Office of Biostatistics (H.D.), Medical College of  Georgia, Augusta, Ga."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(96)00009-9"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.27.6.1210"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117803"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Anderson NB McNeilly M Myers H. Toward understanding race difference in autonomic reactivity. In: Turner JR Sherwood A Light KC eds. Individual Differences in Cardiovascular Response to Stress. New York NY: Plenum Press; 1992:125\u2013145.","DOI":"10.1007\/978-1-4899-0697-7_7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Light KC Sherwood A Turner JR. High cardiovascular reactivity to stress: A predictor of later hypertension development. In: Turner JR Sherwood A Light KC eds. Individual Differences in Cardiovascular Response to Stress. New York NY: Plenum Press; 1992:281\u2013293.","DOI":"10.1007\/978-1-4899-0697-7_15"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm0101_2"},{"key":"e_1_3_2_7_2","unstructured":"Treiber FA Davis H Turner JR. Cardiovascular responsivity to stress and preclinical manifestations of cardiovascular disease in youth. In: Hayman L McMahon M Turner JR eds. 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