{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:16:27Z","timestamp":1759482987217},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014We analyzed the  effects of a possible interaction between nitric oxide deficiency and  mineralocorticoids on the long-term control of blood pressure and renal  and endocrine variables. Six groups of uninephrectomized male  Wistar rats were used: control animals and rats that received (1)\n            <jats:italic>N<\/jats:italic>\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methyl ester  (L-NAME) subpressor (0.5 mg\/100 mL drinking fluid), (2) L-NAME pressor  (35 mg\/100 mL drinking fluid), (3) deoxycorticosterone acetate (DOCA;  12.5 mg\/wk per rat), (4) DOCA plus L-NAME subpressor, or (5) L-NAME  pressor plus DOCA. For all groups, the drinking fluid was tap water or  1% NaCl solution. We measured the time course of tail systolic  blood pressure (SBP) and body weight for 3 weeks in all rats. At the  end of the experimental period, we measured mean arterial  pressure (direct recording) and endocrine and renal  variables. Tail SBP rose significantly in the DOCA plus L-NAME  subpressor\u2013treated group but remained at normotensive levels in the  DOCA-treated group. The addition of L-NAME to the subpressor dose  accelerated the blood pressure increase in DOCA-salt hypertensive rats.  The simultaneous administration of DOCA and L-NAME  increased blood pressure and mortality rates in rats that drank water  or saline compared with the rats treated with L-NAME alone. The  subpressor dose of L-NAME did not increase blood pressure in  saline-drinking rats. We conclude that impaired NO synthesis results in  increased sensitivity to the pressor effect of mineralocorticoids in  the presence or absence of an increased saline intake. Hence, nitric  oxide contributes to the adaptative response to mineralocorticoid  excess, perhaps through the facilitation of natriuresis and, thus,  control of blood pressure.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.3.752","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"752-757","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Interaction Between Nitric Oxide and Mineralocorticoids in the Long-Term Control of Blood Pressure"],"prefix":"10.1161","volume":"35","author":[{"given":"Gracia","family":"Alvarez","sequence":"first","affiliation":[{"name":"From the Departamento de Fisiologi\u0301a, Facultad de Medicina,  Servicio de Nefrologi\u0301a, Unidad Experimental, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Osuna","sequence":"additional","affiliation":[{"name":"From the Departamento de Fisiologi\u0301a, Facultad de Medicina,  Servicio de Nefrologi\u0301a, Unidad Experimental, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Wangensteen","sequence":"additional","affiliation":[{"name":"From the Departamento de Fisiologi\u0301a, Facultad de Medicina,  Servicio de Nefrologi\u0301a, Unidad Experimental, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fe\u0301lix","family":"Vargas","sequence":"additional","affiliation":[{"name":"From the Departamento de Fisiologi\u0301a, Facultad de Medicina,  Servicio de Nefrologi\u0301a, Unidad Experimental, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.32.6.958"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V291371"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Shultz PJ Tolins JP. 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