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In this review, we present data to indicate  that the reverse is also true; persons of equal weight who had higher  initial blood pressures gain more weight in the future. We also propose  a plausible hypothesis to explain this reverse relationship. Both the  blood pressure elevation and the gain of weight may reflect a primary  increase in sympathetic tone. It is well known that in a milieu of  increased sympathetic tone, the \u03b2-adrenergic responsiveness  decreases. Sympathetic overactivity and decreased  cardiovascular \u03b2-adrenergic responsiveness have been  described in hypertension. \u03b2-Adrenergic receptors mediate increases  in energy expenditure. If these metabolic receptors were  downregulated in hypertension, the ability of hypertensive patients to  dissipate calories would decrease and they would gain more weight. The  possible relationship of decreased \u03b2-adrenergic responsiveness to  weight in hypertension can be experimentally tested. Such research may  contribute to an explanation of why patients with hypertension can  rarely lose weight. An understanding of this  pathophysiological relationship may open new  avenues for therapeutic interventions.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.3.807","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"807-813","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":191,"title":["Overweight and Hypertension"],"prefix":"10.1161","volume":"35","author":[{"given":"Stevo","family":"Julius","sequence":"first","affiliation":[{"name":"From the Division of Hypertension (S.J., M.V.), University of Michigan  Health System, Ann Arbor; and Dipartimento di Medicina Clinica e Sperimentale  (P.P.), University of Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariaconsuelo","family":"Valentini","sequence":"additional","affiliation":[{"name":"From the Division of Hypertension (S.J., M.V.), University of Michigan  Health System, Ann Arbor; and Dipartimento di Medicina Clinica e Sperimentale  (P.P.), University of Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Palatini","sequence":"additional","affiliation":[{"name":"From the Division of Hypertension (S.J., M.V.), University of Michigan  Health System, Ann Arbor; and Dipartimento di Medicina Clinica e Sperimentale  (P.P.), University of Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290150053024"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(90)90017-M"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-67-1-48"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","unstructured":"MacMahon S Cutler J Brittain E Higgins M. 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