{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T16:35:13Z","timestamp":1721234113508},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Aldosterone  and other mineralocorticoids increase citrate synthase activity in the  kidney and enhance renal sodium reabsorption, but it is unclear whether  the increased citrate synthase activity is involved in renal sodium  transport. We used the Wistar-Furth rat, an inbred strain found to be  deficient in renal citrate synthase activity, as an experimental model  to investigate this issue. We confirmed that renal citrate synthase  activity from adrenalectomized Wistar-Furth rats was decreased compared  with that from control Wistar rats (by 28%). Similarly, urinary  citrate excretion was 23% lower in Wistar-Furth rats. Subnormal  citrate formation in Wistar-Furth rats could not be accounted for by  differences in systemic pH or circulating potassium levels. Because  renal citrate synthase activity was reduced in Wistar-Furth rats, we  hypothesized that renal sodium excretory responses to  mineralocorticoids would be reduced as well. Four-hour sodium excretion  after intraperitoneal injection of 5 \u03bcg of  aldosterone was reduced by 56% in adrenalectomized Wistar  rats and by 52% in adrenalectomized Wistar-Furth rats (both\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01 compared with vehicle injection). Similarly, the  pattern of urinary sodium excretion in response to subcutaneous  injections of deoxycorticosterone acetate over a 2-week period was  similar in adrenalectomized Wistar and Wistar-Furth rats. In summary,  acute and chronic antinatriuretic responses to  mineralocorticoids are maintained in Wistar-Furth rats at the level of  Wistar rats, despite the marked reduction in citrate synthase activity.  These findings are not consistent with an important role for  citrate synthase activity in mineralocorticoid-mediated renal  sodium transport.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.4.875","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"875-879","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Role of Citrate Synthase in Aldosterone-Mediated Sodium Reabsorption"],"prefix":"10.1161","volume":"35","author":[{"given":"Michael E.","family":"Ullian","sequence":"first","affiliation":[{"name":"From the Medical University of South Carolina (M.E.U., C.J.R., W.R.F.),  Charleston, SC; University of Texas Southwestern Medical School (C.T.B.E.),  Dallas, Tex; and Northwestern University School of Medicine (J.Z.M.), Chicago,  Ill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Robinson","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (M.E.U., C.J.R., W.R.F.),  Charleston, SC; University of Texas Southwestern Medical School (C.T.B.E.),  Dallas, Tex; and Northwestern University School of Medicine (J.Z.M.), Chicago,  Ill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia T. B.","family":"Evans","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (M.E.U., C.J.R., W.R.F.),  Charleston, SC; University of Texas Southwestern Medical School (C.T.B.E.),  Dallas, Tex; and Northwestern University School of Medicine (J.Z.M.), Chicago,  Ill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel Z.","family":"Melnick","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (M.E.U., C.J.R., W.R.F.),  Charleston, SC; University of Texas Southwestern Medical School (C.T.B.E.),  Dallas, Tex; and Northwestern University School of Medicine (J.Z.M.), Chicago,  Ill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne R.","family":"Fitzgibbon","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (M.E.U., C.J.R., W.R.F.),  Charleston, SC; University of Texas Southwestern Medical School (C.T.B.E.),  Dallas, Tex; and Northwestern University School of Medicine (J.Z.M.), Chicago,  Ill."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.6.3672"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01873339"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009843"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/o72-165"},{"key":"e_1_3_3_5_2","first-page":"85","volume":"12","year":"1989","unstructured":"Minuth WW, Struck M, Zwanzig M, Gross P. 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Resistance to mineralocorticoids in the Wistar-Furth rat. Am J Physiol. 1997;272:H1454\u2013H1461.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_3_15_2","first-page":"F756","volume":"258","year":"1990","unstructured":"Morris DJ, Souness GW. The 11\u03b2-OHSD inhibitor, carbenoxolone, enhances Na retention by aldosterone and 11-deoxycorticosterone. Am J Physiol. 1990;258:F756\u2013F759.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119051"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.35.4.875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:11:51Z","timestamp":1715533911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.35.4.875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1161\/01.HYP.35.4.875"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.35.4.875","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"1999-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}